tesofensine

Product Name: tesofensine
CAS No.: 195875-84-4
Chemical Name: tesofensine
Synonyms: Tesofensine-13C-d3;Tesofensine 0.5mg Tablets;Tesofensine 500mcg Tablets;(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
CBNumber: CB12498844
Molecular Formula: C17H23Cl2NO
Formula Weight: 328.28
MOL File: 195875-84-4.mol

More

Less

tesofensine Property

Boiling point:: 396.6±42.0 °C(Predicted)
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL
form: A solid
pka: 10.46±0.60(Predicted)
color: White to off-white
Stability:: Hygroscopic
InChI: InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1
InChIKey: VCVWXKKWDOJNIT-ZOMKSWQUSA-N
SMILES: [C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=C(Cl)C(Cl)=C1)[C@H]2COCC

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: T136500
Product name: Tesofensine
Packaging: 1mg
Price: $305
Updated: 2021/12/16

More

Less

tesofensine Chemical Properties,Usage,Production

Description

Tesofensine ((1R, 2R, 3S, 5S)-3-(3, 4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane)) is an inhibitor of neuronal reuptake of dopamine, noradrenaline, and serotonin. Tesofensine was developed for the treatment of Alzheimer's and Parkinson's disease but lacked efficacy. Meta-analysis revealed that tesofensine (0.125–1.0 mg, once daily; oral) produced dose-dependent weight loss, and 32% of obese patients had ≥ 5% weight loss following 14 wk of treatment. Weight loss was accompanied by hypophagia, suggesting an appetite suppressant action[2].

History

Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease. Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease. Hence, tesofensine is now being developed by NeuroSearch for the treatment of obesity and type 2 diabetes[1].

Uses

Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.

in vivo

Tesofensine (a single dose of 0.1-3? mg/kg, s.c.) induces hypophagia in the DIO rat. A single dose of Tesofensine (0. 1-3?mg/kg, s.c.) robustly and dose dependently inhibits food intake in DIO rats over the 12?h nocturnal observation period. Daily administration of a moderate dose of Tesofensine (2.0?mg/kg, s.c.) over 16 days triggers a significant reduction in body weight after 4 days of administration relative to vehicle-treated controls^[3].

Animal Model:	Diet-induced obesity (DIO) rat^[3]
Dosage:	0.1-3?mg/kg
Administration:	Administered subcutaneously (s.c.); a single dose (acute treatment)
Result:	The threshold dose for inhibition of total food intake was 1.0?mg/kg. The ED₅₀ for inhibition of total food intake in DIO rats was estimated to be 1.3?mg/kg.

Animal Model:	Diet-induced obesity (DIO) rat^[3]
Dosage:	2.0?mg/kg
Administration:	Administered subcutaneously (s.c.) daily for over 16 days (chronic treatment)
Result:	The average relative decrease in the body weight of tesofensine-treated DIO rats over the entire treatment period was 8.6±1.4%. When comparing to vehicle controls, the relative weight loss with tesofensine was 13.8±1.4%.

References

[1] Dourish, C. J. Wilding and J. Halford. “Anti-obesity Drugs: From Animal Models to Clinical Efficacy.”Animal and Translational Models for CNS Drug Discovery 2008: 271-315.
[2] Vidya Narayanaswami, Linda P. Dwoskin. “Obesity: Current and potential pharmacotherapeutics and targets.” Pharmacology Therapeutics 170 (2017): Pages 116-147.

tesofensine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tesofensine Suppliers

CHINA 34 India 1 United States 4 Global 39

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

DONGGUAN AOME BIOTECHNOLOGY CO.,LTD

Tel: 13790132747
Fax: 0769-87053745
Email: 2784729268@qq.com
Country: China
ProdList: 49
Advantage: 50

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 2081
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81148696 +86-17392712697
Email: 1022@dideu.com
Country: China
ProdList: 3995
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Guangdong Fangxin Biotechnology Co., Ltd.

Tel: 0751-2838688 13376594225
Email: 1276075424@qq.com
Country: China
ProdList: 9942
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 029-029-81123119 17391733320
Email: 1021@dideu.com
Country: China
ProdList: 9995
Advantage: 58

Weifu (Shanghai) Pharmaceutical Technology Co., LTD

Tel: 021-57609736 13917553503
Email: 401919639@qq.com
Country: China
ProdList: 244
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-025-66113011 18626450290
Email: cb5@aikonchem.com
Country: China
ProdList: 10358
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 5830
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 17301488900
Fax: 025-85560043
Email: judy.xia@synzest.com
Country: China
ProdList: 12582
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

Hubei Yanke Times Technology Co., Ltd

Tel: 15780669880 15727070860
Email: 15780669880@163.com
Country: China
ProdList: 997
Advantage: 58

Zibo Hangyu Biotechnology Development Co., Ltd

Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Country: China
ProdList: 8510
Advantage: 58

Ningbo Qingteng Plastic Cost.,Ltd.

Tel: 15383911577
Email: admin@nbqingteng.com
Country: China
ProdList: 308
Advantage: 58

Shenzhen Aoxi Technology Co., Ltd.

Tel: +852-46424790
Email: frank88rawpowder@outlook.com
Country: China
ProdList: 161
Advantage: 58

Forest chemical technology

Tel: +85295407470
Email: grant@forestchem.freeqiye.com
Country: China
ProdList: 752
Advantage: 58

Shandong Huizhihan Supply Chain Co., Ltd

Tel: +86-13363081709 +86-13363000288
Email: 3957328362@qq.com
Country: China
ProdList: 115
Advantage: 58

Hebei Dangtong Import and export Co LTD

Tel: +86-86-4001020630 +8619831957301
Email: admin@hbdangtong.com
Country: China
ProdList: 1000
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Shanghai Getian Industrial Co., LTD

Tel: +86-15373193816
Email: mike@ge-tian.com
Country: China
ProdList: 269
Advantage: 58

Hebei Weimiao Import and Export Trade Co., Ltd.

Tel: +86-19948166995
Email: sale01@hbweimiao.com
Country: China
ProdList: 76
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

More

Less

View Lastest Price from tesofensine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Tesofensine 195875-84-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 200 kgs
Release date: 2025-09-13

Shaanxi Dideu Medichem Co. Ltd

Product: tesofensine 195875-84-4
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2025-08-26

Ningbo Qingteng Plastic Cost.,Ltd.

Product: Tesofensine 195875-84-4
Price: US $10.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100000box
Release date: 2025-08-25

195875-84-4, tesofensineRelated Search:

(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane

(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane

Tesofensine-13C-d3

8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-

Tesofensine 500mcg Tablets

Tesofensine 0.5mg Tablets

195875-84-4