3-Amino-4-(trifluoromethyl)benzonitrile
- Product Name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- CAS No.
- 1220630-83-0
- Chemical Name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- Synonyms
- 3-Amino-4-(trifluoromethyl);3-Amino-4-(trifluoromethyl)benzonitrile;Benzonitrile, 3-amino-4-(trifluoromethyl)-;2-Amino-4-cyanobenzotrifluoride, 5-Cyano-alpha,alpha,alpha-trifluoro-o-toluidine
- CBNumber
- CB12499003
- Molecular Formula
- C8H5F3N2
- Formula Weight
- 186.13
- MOL File
- 1220630-83-0.mol
3-Amino-4-(trifluoromethyl)benzonitrile Property
- Boiling point:
- 286.6±40.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -0.35±0.10(Predicted)
- form
- crystalline powder
- color
- Light gold to sand coloured
Safety
- HS Code
- 2926907090
N-Bromosuccinimide Price
- Product number
- A630635
- Product name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A630635
- Product name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 126646
- Product name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- Purity
- >95%
- Packaging
- 1g
- Price
- $188
- Updated
- 2021/12/16
- Product number
- PC49084
- Product name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- Packaging
- 5g
- Price
- $241
- Updated
- 2021/12/16
- Product number
- 3837-3-39
- Product name
- 3-Amino-4-(trifluoromethyl)benzonitrile
- Packaging
- 5G
- Price
- $266
- Updated
- 2021/12/16
3-Amino-4-(trifluoromethyl)benzonitrile Chemical Properties,Usage,Production
Synthesis
1220630-84-1
1220630-83-0
Procedure for the preparation of 3-amino-4-(trifluoromethyl)benzonitrile: 3-(4-methoxybenzylamino)-4-(trifluoromethyl)benzonitrile (500 mg, 1.63 mmol) and triethylsilane (0.2 mL) were dissolved in dichloroethane (2 mL), trifluoroacetic acid (TFA, 1 mL) was added, and the reaction was stirred for 30 min at room temperature. After completion of the reaction, the reaction mixture was concentrated to give Intermediate 24 (284 mg, 93% yield) as an orange solid. It was analyzed by high performance liquid chromatography (HPLC) using a Phenomenex? S5 4.6×30 mm column with a 10-90% aqueous methanol solution containing 0.1% TFA as the mobile phase in a 4-minute gradient elution at a flow rate of 5 mL/min and a detection wavelength of 254 nm, with a retention time (Rt) of 1.24 min. Mass spectrometry (MS) analysis showed m/z = 187.1 [M + H]+. This intermediate 24 was used in the synthesis of subsequent Examples 229, 230 and 241.
References
[1] Patent: WO2010/42699, 2010, A1. Location in patent: Page/Page column 72
3-Amino-4-(trifluoromethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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