methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
- Product Name
- methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
- CAS No.
- 26845-47-6
- Chemical Name
- methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
- Synonyms
- methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate;1,4-Dioxaspiro[4.5]decane-8-carboxylic Acid Methyl Ester
- CBNumber
- CB12499290
- Molecular Formula
- C10H16O4
- Formula Weight
- 200.23
- MOL File
- 26845-47-6.mol
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Property
- Boiling point:
- 96-100 °C
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- color
- Colorless to Almost colorless
- CAS DataBase Reference
- 26845-47-6
Safety
- HS Code
- 2932.99.9090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M3273
- Product name
- Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate
- Packaging
- 1G
- Price
- $68
- Updated
- 2025/07/31
- Product number
- M3273
- Product name
- Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate
- Packaging
- 5G
- Price
- $237
- Updated
- 2025/07/31
- Product number
- M303680
- Product name
- Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- M303680
- Product name
- Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 132067
- Product name
- Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $2674
- Updated
- 2021/12/16
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Chemical Properties,Usage,Production
Uses
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is a reagnet used in the preparation of pharmaceutical compounds such as high affinity H3 receptor agonists and reverse hydroxamate-based selective TACE inhibitors.
Synthesis
6297-22-9
107-21-1
26845-47-6
Step 1: Synthesis of methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 1.3 g of methyl 4-oxocyclohexanecarboxylate, 0.64 g of ethylene glycol and 0.14 g of p-toluenesulfonic acid were added to 40 mL of toluene. The mixed solution was refluxed and stirred overnight in the presence of a Dean-Stark water separator to remove the water generated. Upon completion of the reaction, the toluene solvent was removed by distillation under reduced pressure. Subsequently, the reaction mixture was separated by extraction with 50 mL of diethyl ether and 50 mL of water. The organic phase was dried with anhydrous magnesium sulfate, filtered and purified by reduced pressure distillation (138~145 °C, 15 mmHg) to afford 0.42 g of the oily target product methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate. The product was characterized by NMR (300 MHz, CDCl3): δ 3.95 (s, 4H), 3.67 (s, 3H), 2.36~2.32 (m, 1H), 1.94~1.91 (m, 2H), 1.83~1.75 (m, 4H), 1.61~1.55 (m, 2H).
References
[1] Journal of Organic Chemistry, 1997, vol. 62, # 16, p. 5284 - 5292
[2] Recueil: Journal of the Royal Netherlands Chemical Society, 1980, vol. 99, # 2, p. 53 - 57
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[4] Patent: WO2007/6760, 2007, A1. Location in patent: Page/Page column 109-110; 130-131
[5] Patent: EP1860089, 2007, A1. Location in patent: Page/Page column 21-22
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate manufacturers
- Product
- Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 26845-47-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-09-26