2,5,6-tetrachloropyridine
- Product Name
- 2,5,6-tetrachloropyridine
- CAS No.
- 54718-39-7
- Chemical Name
- 2,5,6-tetrachloropyridine
- Synonyms
- 2,5,6-Trichloronicotinic acid;2,5,6-TrichL;Trichloronicotinic acid; 2,5,6-tetrachloropyridine;2,5,6-trichloropyridine-3-carboxylicaci;2,5,6-Trichloro-3-pyridinecarboxylic acid;2,5,6-Trichloropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2,5,6-trichloro-;2,5,6-Trichloronicotinic acid ISO 9001：2015 REACH
- CBNumber
- CB12500567
- Molecular Formula
- C6H2Cl3NO2
- Formula Weight
- 226.44
- MOL File
- 54718-39-7.mol
2,5,6-tetrachloropyridine Property
- Melting point:
- 158-161 °C
- Boiling point:
- 359.1±37.0 °C(Predicted)
- Density
- 1.728
- storage temp.
- 2-8°C
- pka
- 1.35±0.32(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H2Cl3NO2/c7-3-1-2(6(11)12)4(8)10-5(3)9/h1H,(H,11,12)
- InChIKey
- XMJRZCYSCMZVJQ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C(Cl)C=C1C(O)=O
Safety
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T798318
- Product name
- 2,5,6-TrichloronicotinicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Z4869
- Product name
- 2,5,6-Trichloronicotinicacid
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
- Product number
- J96312
- Product name
- 2,5,6-Trichloronicotinicacid
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Z4869
- Product name
- 2,5,6-Trichloronicotinicacid
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- CS-W019671
- Product name
- 2,5,6-Trichloronicotinicacid
- Purity
- 99.57%
- Packaging
- 5g
- Price
- $124
- Updated
- 2021/12/16
2,5,6-tetrachloropyridine Chemical Properties,Usage,Production
Description
It has been reported that on treatment with lithium aluminium hydride pentafluoropyridine gives 2,5,6-tetrafluoropyridine and that further reduction occurs at the 2-position as expected from a hydride attack.
Uses
2,5,6-tetrachloropyridine belongs to carboxylic acid organic compounds and can be used as pharmaceutical intermediates.
Synthesis
58584-95-5
54718-39-7
General procedure for the synthesis of 2,5,6-trichloronicotinic acid from 2,3,6-trichloro-5-methylpyridine: 2,3,6-trichloro-5-methylpyridine (18.8 g, 60.0 mmol) was suspended in water (400 ml) and heated to 100 °C. Subsequently, potassium permanganate (KMnO4, 28.5 g, 180.2 mmol) was added in batches over 12 hours. The reaction mixture was stirred continuously at 100 °C for 2 days, during which additional potassium permanganate (10 g) was added. After confirming the complete consumption of raw materials by TLC monitoring, the reaction mixture was filtered while hot and washed with hot water (2 x 75 ml). The combined filtrates were cooled to room temperature and extracted with ethyl acetate (EtOAc, 3 x 100 ml). The aqueous phase was concentrated to about 50 ml, cooled to 0 °C and the pH was adjusted to 1-2 with 6.0 M hydrochloric acid.The precipitated solid was collected by filtration, washed with cold water and dried to afford the target product 2,5,6-trichloronicotinic acid (2.5 g, 18% yield), which was used in subsequent reactions without further purification.
References
[1] Patent: WO2006/82392, 2006, A1. Location in patent: Page/Page column 109-110
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 2958 - 2961
2,5,6-tetrachloropyridine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2,5,6-tetrachloropyridine manufacturers
- Product
- 2,5,6-Trichloronicotinic acid 54718-39-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-19
- Product
- 2,5,6-tetrachloropyridine 54718-39-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18
- Product
- 2,5,6-Trichloronicotinic acid 54718-39-7
- Price
- US $10.50/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 0.99
- Supply Ability
- 1KG
- Release date
- 2021-09-24