6-Hydroxy-2-methylbenzoxazole

Product Name: 6-Hydroxy-2-methylbenzoxazole
CAS No.: 5078-07-9
Chemical Name: 6-Hydroxy-2-methylbenzoxazole
Synonyms: 2-Methyl-benzooxazol-6-ol;6-Benzoxazolol, 2-Methyl-;2-Methylbenzo[d]oxazol-6-ol;2-methyl-1,3-benzoxazol-6-ol;6-Hydroxy-2-methylbenzoxazole;2-methyl-1,3-benzoxazol-6-ol(SALTDATA: FREE)
CBNumber: CB12500653
Molecular Formula: C8H7NO2
Formula Weight: 149.15
MOL File: 5078-07-9.mol

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6-Hydroxy-2-methylbenzoxazole Property

Melting point:: 196 °C
Boiling point:: 278.7±13.0 °C(Predicted)
Density: 1.305
storage temp.: 2-8°C
pka: 8.49±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR949663
Product name: 2-Methylbenzo[d]oxazol-6-ol
Purity: 95%
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Matrix Scientific

Product number: 157023
Product name: 2-Methyl-1,3-benzoxazol-6-ol
Packaging: 0.500g
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: OR949663
Product name: 2-Methylbenzo[d]oxazol-6-ol
Purity: 95%
Packaging: 1g
Price: $285
Updated: 2021/12/16

Matrix Scientific

Product number: 157023
Product name: 2-Methyl-1,3-benzoxazol-6-ol
Packaging: 1g
Price: $300
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126961
Product name: 2-METHYL-1,3-BENZOXAZOL-6-OL
Purity: 95.00%
Packaging: 1G
Price: $818.61
Updated: 2021/12/16

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6-Hydroxy-2-methylbenzoxazole Chemical Properties,Usage,Production

Synthesis Reference(s)

Synthesis, p. 68, 1982 DOI: 10.1055/s-1982-29704

Synthesis

111364-29-5

5078-07-9

The general procedure for the synthesis of 2-methyl-6-hydroxybenzoxazole from the compound (CAS:111364-29-5) was as follows: (1Z)-1-(2,4-dihydroxyphenyl)ethanone oxime (9.7 g, 57.7 mmol) was dissolved in a mixed solvent of acetonitrile (65 mL) and dimethylacetamide (11 mL) and cooled to 5 °C. Phosphorus trichloride (5.6 mL, 60.3 mmol) was slowly added dropwise at a temperature not exceeding 10 °C. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 h. The reaction solution gradually formed a yellow slurry. The reaction mixture was carefully poured into a pre-prepared mixture of sodium bicarbonate and ice for neutralization. The resulting precipitate was collected by filtration and dried to give 6.3 g of 2-methyl-6-hydroxybenzoxazole in 73% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4313 - 4316
[2] Patent: WO2004/5295, 2004, A1. Location in patent: Page 99
[3] Patent: WO2005/61499, 2005, A1. Location in patent: Page/Page column 41
[4] Patent: WO2005/37814, 2005, A1. Location in patent: Page/Page column 35

6-Hydroxy-2-methylbenzoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Hydroxy-2-methylbenzoxazole Suppliers

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5078-07-9, 6-Hydroxy-2-methylbenzoxazoleRelated Search:

6-Hydroxy-2-methylbenzoxazole

2-methyl-1,3-benzoxazol-6-ol(SALTDATA: FREE)

2-Methylbenzo[d]oxazol-6-ol

6-Benzoxazolol, 2-Methyl-

2-methyl-1,3-benzoxazol-6-ol

2-Methyl-benzooxazol-6-ol

5078-07-9