4,5-Dibromo-2H-1,2,3-triazole
- Product Name
- 4,5-Dibromo-2H-1,2,3-triazole
- CAS No.
- 22300-52-3
- Chemical Name
- 4,5-Dibromo-2H-1,2,3-triazole
- Synonyms
- 2H-1,2,3-Triazole, 4,5-dibromo-
- CBNumber
- CB12500709
- Molecular Formula
- C2HBr2N3
- Formula Weight
- 226.86
- MOL File
- 22300-52-3.mol
4,5-Dibromo-2H-1,2,3-triazole Property
- Boiling point:
- 347.5±22.0 °C(Predicted)
- Density
- 2.620
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 5.22±0.70(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C2HBr2N3/c3-1-2(4)6-7-5-1/h(H,5,6,7)
- InChIKey
- GUQUYKTWVBJKFL-UHFFFAOYSA-N
- SMILES
- N1=C(Br)C(Br)=NN1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D426248
- Product name
- 4,5-Dibromo-2H-triazole
- Packaging
- 5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- P000087782
- Product name
- 4,5-Dibromo-2H-1,2,3-triazole
- Purity
- 98%
- Packaging
- 250mg
- Price
- $5
- Updated
- 2021/12/16
- Product number
- P000087782
- Product name
- 4,5-Dibromo-2H-1,2,3-triazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $9
- Updated
- 2021/12/16
- Product number
- P000087782
- Product name
- 4,5-Dibromo-2H-1,2,3-triazole
- Purity
- 98%
- Packaging
- 5g
- Price
- $33
- Updated
- 2021/12/16
- Product number
- J20520
- Product name
- 4,5-Dibromo-2H-1,2,3-triazole
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
4,5-Dibromo-2H-1,2,3-triazole Chemical Properties,Usage,Production
Uses
4,5-Dibromo-2H-triazole was a useful reagent in discovery of selective small molecular inhibitors of monoacylglycerol acyltransferase 3.
Synthesis
288-36-8
22300-52-3
To a 3000 mL three-necked round-bottomed flask was added 2H-1,2,3-triazole (100 g, 1.45 mol, 1.00 eq.) and water (1000 mL), followed by the slow addition of bromine (Br2, 522 g, 3.27 mol, 2.25 eq.). The reaction mixture was placed in a 50 °C oil bath and the reaction was stirred overnight. Upon completion of the reaction, the reaction was quenched by the slow addition of 1000 mL of aqueous sodium sulfite (Na2SO3). The reaction mixture was separated by filtration and the solid product was collected. The resulting solid was dried in an oven under reduced pressure to give 4,5-dibromo-2H-1,2,3-triazole (313 g, 95% yield) as a white solid.
References
[1] Organic Letters, 2010, vol. 12, # 20, p. 4632 - 4635
[2] Patent: US2017/166584, 2017, A1. Location in patent: Paragraph 0718; 0719
[3] Patent: WO2012/151512, 2012, A2. Location in patent: Page/Page column 151
[4] Patent: WO2015/74064, 2015, A2. Location in patent: Paragraph 0260
[5] Patent: WO2018/111803, 2018, A1. Location in patent: Page/Page column 24
4,5-Dibromo-2H-1,2,3-triazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,5-Dibromo-2H-1,2,3-triazole manufacturers
- Product
- 4,5-Dibromo-2H-1,2,3-triazole 22300-52-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-09-04
- Product
- 4,5-Dibromo-2H-1,2,3-triazole 22300-52-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- 1ton
- Release date
- 2019-12-18