Casein Kinase II Inhibitor III
- Product Name
- Casein Kinase II Inhibitor III
- CAS No.
- 934358-00-6
- Chemical Name
- Casein Kinase II Inhibitor III
- Synonyms
- TBCA;Tetrabromocinnamic acid;SVJQCVOKYJWUBC-OWOJBTEDSA-N;Casein Kinase II Inhibitor III;Casein Kinase II Inhibitor III, TBCA;(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic Acid;InSolution? Casein Kinase II Inhibitor III, TBCA;(2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic acid;2-Propenoic acid, 3-(2,3,4,5-tetrabromophenyl)-, (2E)-;Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem
- CBNumber
- CB12501559
- Molecular Formula
- C9H4Br4O2
- Formula Weight
- 463.74
- MOL File
- 934358-00-6.mol
Casein Kinase II Inhibitor III Property
- Melting point:
- 189.2-191.2 °C
- Boiling point:
- 490.8±45.0 °C(Predicted)
- Density
- 2.443±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 3.83±0.16(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 218861
- Product name
- InSolution? Casein Kinase II Inhibitor III, TBCA
- Packaging
- 5mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 218710
- Product name
- Casein Kinase II Inhibitor III, TBCA
- Packaging
- 5mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 14831
- Product name
- TBCA
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 14831
- Product name
- TBCA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- SML0854
- Product name
- TBCA
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
Casein Kinase II Inhibitor III Chemical Properties,Usage,Production
Uses
Casein Kinase II Inhibitor III is a casein kinase 2 inhibitor. A protein kinase inhibitors used to elucidate cellular signaling pathways.
Biological Activity
tetrabromocinnamic acid (tbca) is a new class of specific protein kinase ck2 inhibitors [1].protein kinases have been involved in catalyzing the phosphorylation of serine, threonine and tyrosine residues in protein substrates that play dominant roles in controlling nearly all cellular functions. the ser/thr-specific protein kinase ck2 has been implicated in signal transduction, gene expression, dna repair, rna and protein synthesis. ck2 is invariably elevated in a wide spectrum of tumours [1].
in vitro
tbca was a selective, cell-permeable inhibitor of ck2 with an ic50 of 0.11 μm. the ki value was 77 nm. tbca showed minimal effect on a panel of 28 other kinases. tbca induced cell death in jurkat adult t cell leukemia cells with an dc50 of 7.7 μm [1]. tbca dose-dependently inhibited platelet aggregation and secretion induced by various agonists including 2-mesadp, aypgkf, sfllrn, and crp [2]. tbca also significantly inhibited agonist-induced thromboxane a2 (txa2) generation and erk phosphorylation. tbca significantly inhibited platelet spreading on immobilized fibrinogen surface and clot retraction mediated by integrin αiibβ3 signaling [2].
storage
Store at +4°C
References
[1] pagano m a, poletto g, di maira g, et al. tetrabromocinnamic acid (tbca) and related compounds represent a new class of specific protein kinase ck2 inhibitors[j]. chembiochem, 2007, 8(1): 129-139.
[2] ryu s y, kim s. evaluation of ck2 inhibitor (e)-3-(2, 3, 4, 5-tetrabromophenyl) acrylic acid (tbca) in regulation of platelet function[j]. european journal of pharmacology, 2013, 720(1): 391-400.
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