ChemicalBook > CAS DataBase List > 3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one

3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one

Product Name: 3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one
CAS No.: 56008-20-9
Chemical Name: 3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one
Synonyms: 6,7-dihydro-3,6,6-trimethyl-1H-indol-4(5H)-one;3,6,6-TriMethyl-1,5,6,7-tetrahydro-indol-4-one;3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one;1,5,6,7-Tetrahydro-3,6,6-trimethyl-4H-indol-4-one;4H-Indol-4-one, 1,5,6,7-tetrahydro-3,6,6-trimethyl-
CBNumber: CB12506145
Molecular Formula: C11H15NO
Formula Weight: 177.24
MOL File: 56008-20-9.mol

Less

3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one Property

Melting point:: 156 °C
Boiling point:: 320.0±21.0 °C(Predicted)
Density: 1.069±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 16.24±0.40(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 8182AB
Product name: 3,6,6-Trimethyl-6,7-dihydro-1H-indol-4(5H)-one
Packaging: 100mg
Price: $151
Updated: 2021/12/16

AK Scientific

Product number: 8182AB
Product name: 3,6,6-Trimethyl-6,7-dihydro-1H-indol-4(5H)-one
Packaging: 250mg
Price: $212
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0378238
Product name: 3,6,6-TRIMETHYL-6,7-DIHYDRO-1H-INDOL-4(5H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $501.26
Updated: 2021/12/16

AK Scientific

Product number: 8182AB
Product name: 3,6,6-Trimethyl-6,7-dihydro-1H-indol-4(5H)-one
Packaging: 5g
Price: $1265
Updated: 2021/12/16

Chemenu

Product number: CM125648
Product name: 3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indol-4-one
Purity: 95%
Packaging: 10g
Price: $1393
Updated: 2021/12/16

Less

3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one Chemical Properties,Usage,Production

Synthesis

17280-41-0

126-81-8

56008-20-9

Step 1. Synthesis of 3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one: (E)-acetone aldehyde-1-oxime (0.50 g, 5.74 mmol) and 5,5-dimethyl-1,3-cyclohexanedione (0.80 g, 5.74 mmol) were dissolved in a mixed solvent of acetic acid (35 mL) and water (15 mL). Zinc powder (0.75 g, 11.5 mmol) was slowly added to the reaction system at room temperature. The reaction mixture was refluxed under stirring conditions. After completion of the reaction, the reaction solution was concentrated under reduced pressure and subsequently extracted with dichloromethane and saturated brine. The pH of the aqueous phase was adjusted with saturated sodium bicarbonate solution to 6. The aqueous phase was again extracted with dichloromethane and the organic layers were combined and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure to give the crude product. Purification of the crude product by silica gel column chromatography (eluent: hexane/ethyl acetate, 1/3) afforded 3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one as a yellow solid (4.9 g, 52% yield).

References

[1] Patent: WO2013/62344, 2013, A1. Location in patent: Page/Page column 87
[2] Patent: WO2006/91963, 2006, A1. Location in patent: Page/Page column 84; 89
[3] Patent: US2008/269193, 2008, A1. Location in patent: Page/Page column 39
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4288 - 4305
[5] Patent: US2007/207984, 2007, A1. Location in patent: Page/Page column 23

3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one Suppliers

China 34 India 1 United States 3 Global 38

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Zhuzhou focus pharmaceutical technology co., LTD

Tel: +86-13776644403
Email: robert@focuspharma.cc
Country: China
ProdList: 2459
Advantage: 58

Hunan Jibang Biological Technology Co., LTD

Tel: +8613776644403
Email: sales02@kingboomtech.com
Country: China
ProdList: 1804
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9947
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054;
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Shanghai Hansi Chemical Industry Co., Ltd.

Tel: 17717618050
Email: zllg@gh-reagent.com
Country: China
ProdList: 10420
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 11681
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49941
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Guangzhou Aoz Biotechnology Co., Ltd.

Tel: 18022383332
Country: CHINA
ProdList: 0
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6973
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Shanghai Jingke Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jingkehuaxue@163.com
Country: CHINA
ProdList: 6141
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Shanghai Shize Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shizezjp@163.com
Country: CHINA
ProdList: 6174
Advantage: 58

Shanghai Caiyou Industrial Co., Ltd.

Tel: --
Fax: --
Email: 15821073967@163.com
Country: CHINA
ProdList: 6748
Advantage: 58

Shanghai yiji industries Co., Ltd.

Tel: --
Fax: --
Email: yiji01@foxmail.com
Country: China
ProdList: 6021
Advantage: 50

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Debye Scientific Corporation

Tel: --
Fax: --
Country: China
ProdList: 6891
Advantage: 50

56008-20-9, 3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-oneRelated Search:

Indole

6,7-dihydro-3,6,6-trimethyl-1H-indol-4(5H)-one

1,5,6,7-Tetrahydro-3,6,6-trimethyl-4H-indol-4-one

3,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one

3,6,6-TriMethyl-1,5,6,7-tetrahydro-indol-4-one

4H-Indol-4-one, 1,5,6,7-tetrahydro-3,6,6-trimethyl-

56008-20-9