ChemicalBook > CAS DataBase List > 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone

Product Name
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
CAS No.
1125812-58-9
Chemical Name
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
Synonyms
1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one;afoxolaner-002;afoxolaner Impurity 6;1-[3-Chloro-5-trifluoromethylphenyl;2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone;3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone;3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone;1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone;1-[3-Chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroketone;Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-
CBNumber
CB12514588
Molecular Formula
C9H3ClF6O
Formula Weight
276.56
MOL File
1125812-58-9.mol
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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Property

Boiling point:
203℃
Density 
1.512
Flash point:
77℃
storage temp. 
2-8°C
InChI
InChI=1S/C9H3ClF6O/c10-6-2-4(7(17)9(14,15)16)1-5(3-6)8(11,12)13/h1-3H
InChIKey
KPHAJQJWTSUTQU-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC(C(F)(F)F)=CC(Cl)=C1)C(F)(F)F
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS146793
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95%
Packaging
1g
Price
$120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0361882
Product name
1-(3-CHLORO-5-(TRIFLUOROMETHYL)PHENYL)-2,2,2-TRIFLUOROETHANONE
Purity
95.00%
Packaging
0.25G
Price
$243
Updated
2021/12/16
Ambeed
Product number
A744788
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95+%
Packaging
5g
Price
$255
Updated
2021/12/16
Crysdot
Product number
CD12179721
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95+%
Packaging
5g
Price
$750
Updated
2021/12/16
Chemenu
Product number
CM274874
Product name
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone
Purity
95+%
Packaging
500g
Price
$5520
Updated
2021/12/16
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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Chemical Properties,Usage,Production

Uses

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


Cool the solution containing compound III (74.4g, 0.255mol containing compound III) to -100, and add 120g of sulfuric acid with a mass fraction of 92.5% to the above system while keeping the temperature below 0. After acidification, continue to react and keep for 1.5h, and then add 126.7g of 33% sodium nitrite aqueous solution (containing diazotizing reagent sodium nitrite 0.612mol) into the system uniformly within 2h, and keep the temperature at 0 The following reaction is carried out for 2 hours, and the system is heated to room temperature after full reaction, 111.1 g of 50% hypophosphorous acid and 0.67 g of cuprous oxide are added, and the reaction is stirred for 2 hours while keeping temperature. After the reaction is over, stand to separate the layers, and wash the organic layer with a 5% sodium bicarbonate aqueous solution, dry with anhydrous magnesium sulfate, and rectify to obtain a clear and transparent oily liquid 1-[3-chloro-5-(trifluoromethyl) (Yl)phenyl]-2,2,2-trifluoroethanone 66.9, content 99.5%, yield 87.2%.

1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone Suppliers

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View Lastest Price from 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone 1125812-58-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-09-22
Shaanxi Dideu New Materials Co. Ltd
Product
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone 1125812-58-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-07-04
Wuhan Biocar Pharmacy CO.,Ltd.
Product
1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one 1125812-58-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
500kg
Release date
2025-03-26

1125812-58-9, 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanoneRelated Search:


  • 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
  • 3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone
  • 2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone
  • 3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone
  • 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one
  • Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-
  • 1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one (Afoxolaner intermediate）
  • 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone ISO 9001：2015 REACH
  • afoxolaner-002
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  • 1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanoneISO9001：2015R
  • 1-(3-chloro-5-(trifluoromethyl)pChemicalbookhenyl)-2,2,2-trifluoroethan-1-one
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