HNHA

Product Name: HNHA
CAS No.: 926908-04-5
Chemical Name: HNHA
Synonyms: HNHA;HNHAHDAC inhibitor;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
CBNumber: CB12514669
Molecular Formula: C17H21NO2S
Formula Weight: 303.42
MOL File: 926908-04-5.mol

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HNHA Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: Crystalline solid
Sensitive: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J64917
Product name: HNHA
Packaging: 10mg
Price: $167
Updated: 2021/12/16

Cayman Chemical

Product number: 13295
Product name: HNHA
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 13295
Product name: HNHA
Purity: ≥98%
Packaging: 10mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 13295
Product name: HNHA
Purity: ≥98%
Packaging: 25mg
Price: $374
Updated: 2024/03/01

AK Scientific

Product number: 1789AH
Product name: HNHA
Packaging: 25mg
Price: $513
Updated: 2021/12/16

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HNHA Chemical Properties,Usage,Production

Description

HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC₅₀ = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC₅₀ ~ 7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.

Uses

A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity

Definition

ChEBI: N-hydroxy-7-(2-naphthalenylthio)heptanamide is a member of naphthalenes.

in vitro

previous study found that hnha was able to inhibit in-vitro hdac enzyme activity as well as proliferation of human fibrosarcoma cells (ht1080). in addition, treatment of cells with hnha could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of ht1080 cell invasion [1].

in vivo

the effects of hnha on human cancer cells bearing xenograph mice was examined. results showed that as expected, hnha could dramatically reduce tumor volume as to (vehicle) control. in addition, hnha had a stronger potency than that of saha, which implied that the pharmacological potency of hnha was better than saha in vivo [1].

IC 50

100 nm

References

1. kim, d.h.,lee, j.,kim, k.n., et al. anti-tumor activity of n-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. biochemical and biophysical research communications 356, 233-238 (2007).

HNHA Preparation Products And Raw materials

Raw materials

Preparation Products

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HNHA Suppliers

China 34 United States 6 Global 40

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926908-04-5, HNHARelated Search:

HNHAHDAC inhibitor

N-hydroxy-7-(2-naphthalenylthio)-Heptanamide

HNHA

Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-

N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide

Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC

926908-04-5

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