ChemicalBook > CAS DataBase List > (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Product Name
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
CAS No.
254750-02-2
Chemical Name
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Synonyms
EMricasan;CS-1040;CS-2634;IDN 6556;abs816139;PF 03491390;Emricasan, (IDN-6556;Emricasan, PF 03491390;Emricasan, 10 mM in DMSO;Emricasan(IDN6556,PF03491390)
CBNumber
CB12514861
Molecular Formula
C26H27F4N3O7
Formula Weight
569.51
MOL File
254750-02-2.mol
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(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Property

Density 
1.386
storage temp. 
-20°C
solubility 
DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)
pka
3.91±0.19(Predicted)
form 
powder
color 
white to beige
CAS DataBase Reference
254750-02-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2227
Product name
Emricasan
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2227
Product name
Emricasan
Purity
≥98% (HPLC)
Packaging
25mg
Price
$528
Updated
2025/07/31
Cayman Chemical
Product number
22204
Product name
Emricasan
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
22204
Product name
Emricasan
Purity
≥98%
Packaging
5mg
Price
$76
Updated
2024/03/01
Cayman Chemical
Product number
22204
Product name
Emricasan
Purity
≥95%
Packaging
25 mg
Price
$253
Updated
2024/03/01
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(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Chemical Properties,Usage,Production

Uses

Emricasan is an irreversible pan-caspase inhibitor that hinders caspase-mediated apoptosis and inflammation.?In addition, Emricasan may reduce hepatic injury and liver fibrosis.

Biological Activity

Emricasan is an antiapoptotic pan-caspase inhibitor. It has been in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) with advanced fibrosis (scarring) and cirrhosis. Emricasan has also been shown to protect infected astrocytes from ZIKV-induced cell death.', 'Emricasan, formerly known as IDN-6556, in combination with birinapan is used to tre at acute myeloid leukemia (AML). This small molecule irreversible inhibitor is under clinical investigation to reduce hepatic injury and liver fibrosis.

in vivo

Emricasan (PF 03491390; IDN-6556) is orally active that is retained in the liver for a prolonged period of time. TUNEL-positive cells are considerably increased by five-fold in mice fed a HFD and are reduced under Emricasan treatment. In accordance with this observation caspase-3 and -8 are increased in HFD-fed mice by 1.5- and 1.3-fold respectively and are significantly decreased by Emricasan treatment[2].
When comparing efficacy by multiple routes of administration, Emricasan is administered i.p., p.o., i.m., or i.v. (0.03-3 mg/kg). Caspase 3-like activities, measured as DEVD-AMC cleavage, dose dependently decreased with a 92.5% reduction after the highest dose of Emricasan (3 mg/kg). Emricasan is initially tested in the α-Fas model of liver injury, marked hepatocellular apoptosis, and peak ALT activities within 6 h. Emricasan is administered i.p. immediately after administration of α-Fas, ALT activities, measured 6 h later, decreased in a dose-dependent manner with an ED50 value of 0.08 (0.06-0.12) mg/kg[3].
Emricasan is a highly selective pan-caspase inhibitor demonstrating irreversible inhibition and a significant first-pass effect. In both syngeneic mouse islets and human islets transplanted into immunodeficient mice, Emricasan (i.p., 20 mg/kg) given for 7 days post-transplant led to a significantly enhanced rate of diabetes reversal as compared to vehicle[4].

IC 50

Caspase

storage

Store at -20°C

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Suppliers

China 139 India 2 Japan 1 United Kingdom 1 United States 15 Global 158
Adachibio Inc.
Tel
+81-8027837258; +8108027837258
Fax
0081-80278372055
Email
sales@adachibio.com
Country
Japan
ProdList
992
Advantage
58
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View Lastest Price from (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid manufacturers

Dideu Industries Group Limited
Product
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid 254750-02-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17
Career Henan Chemical Co
Product
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid 254750-02-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

254750-02-2, (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acidRelated Search:

3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

  • PF 03491390
  • IDN 6556
  • (3S)-3-[(N-{[(2-tert-butylphenyl)amino](oxo)acetyl}-L-alanyl)amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
  • (S)-3-((S)-2-(2-(2-tert-butylphenylaMino)-2-oxoacetaMido)propana
  • EMricasan
  • N-[2-(tert-butyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
  • (S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetraf
  • EMricasan (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
  • Emricasan, (IDN-6556
  • (S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tet
  • Emricasan(IDN6556,PF03491390)
  • N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
  • (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
  • CS-1040
  • Emricasan, PF 03491390
  • CS-2634
  • IDN 6556; PF 03491390; PF03491390; PF-03491390; IDN-6556;IDN6556;PF03491390
  • IDN-6556;PF-03491390;PF03491390
  • L-Alaninamide, N-[2-(1,1-dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-
  • (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid USP/EP/BP
  • abs816139
  • (3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
  • (S) -3- (((S) -2- (2- (t-butylphenyl) amino) -2-oxoacetamido) propionamido) -4-oxo-5- (2,3,5,6-tetrafluorophenoxy) valeric acid
  • Emricasan, 10 mM in DMSO
  • Emricasan，IDN-6556，PF 03491390，PF-03491390
  • 254750-02-2
  • C26H27F4N3O7
  • C26H27F4NO7