4-methyl-7-nitro-1H-indole-3-carbonitrile
- Product Name
- 4-methyl-7-nitro-1H-indole-3-carbonitrile
- CAS No.
- 289483-82-5
- Chemical Name
- 4-methyl-7-nitro-1H-indole-3-carbonitrile
- Synonyms
- 4-methyl-7-nitro-1H-indole-3-carbonitrile;4-methyl-7-nitro-1H-indole-4-carbonitrile;1H-Indole-3-carbonitrile, 4-methyl-7-nitro-
- CBNumber
- CB12514977
- Molecular Formula
- C10H7N3O2
- Formula Weight
- 201.18
- MOL File
- 289483-82-5.mol
4-methyl-7-nitro-1H-indole-3-carbonitrile Property
- Boiling point:
- 469.2±40.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.93±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9435CS
- Product name
- 4-Methyl-7-nitro-1H-indole-3-carbonitrile
- Packaging
- 100mg
- Price
- $444
- Updated
- 2021/12/16
- Product number
- AA002X2R
- Product name
- 4-Methyl-7-nitro-1h-indole-3-carbonitrile
- Purity
- 95+%
- Packaging
- 50mg
- Price
- $196
- Updated
- 2021/12/16
- Product number
- A536360
- Product name
- 4-Methyl-7-nitro-1H-indole-3-carbonitrile
- Purity
- 95+%
- Packaging
- 50mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- AA002X2R
- Product name
- 4-Methyl-7-nitro-1h-indole-3-carbonitrile
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $242
- Updated
- 2021/12/16
- Product number
- A536360
- Product name
- 4-Methyl-7-nitro-1H-indole-3-carbonitrile
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
4-methyl-7-nitro-1H-indole-3-carbonitrile Chemical Properties,Usage,Production
Synthesis
289483-80-3
289483-82-5
GENERAL STEPS: To 740 mL of dimethylformamide (DMF) was slowly added 235 mL (2.52 mol) of phosphoryl chloride (POCl3) at 0 °C and the reaction mixture was stirred at 0 °C for 0.5 hours. Subsequently, 370 g (2.10 mol) of 4-methyl-7-nitro-1H-indole (WO00/50395) solution in DMF (1110 mL) was added dropwise to the reaction system at 0 °C. The reaction mixture was gradually warmed to 60 °C and stirred at this temperature for 2 hours. Upon completion of the reaction, 292 g (4.20 mol) of DMF (1850 mL) solution of hydroxylamine hydrochloride was slowly added dropwise to the system, with the dropwise acceleration controlled to keep the internal temperature below 80 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 60 °C for 40 min. Subsequently, the reaction mixture was poured into 11.1 L of ice water while cooling in an ice bath and stirred overnight. The precipitated solid was collected by filtration and washed with water. The resulting solid was suspended in 11.1 L of water and the pH of the suspension was adjusted to 7 with 1 N sodium hydroxide solution, the solid was again collected by filtration and washed with water to give 412 g of 4-methyl-7-nitro-1H-indole-3-carbonitrile (Yield: 97.6%). The resulting product was confirmed to be consistent with 3-cyano-4-methyl-7-nitro-1H-indole described in WO00/50395 by HPLC analysis.HPLC conditions: mobile phase CH3CN/H2O/70% HClO4 = 500/500/1 (v/v/v), flow rate 1.0 mL/min, detection wavelength 254 nm, column YMC- Pack Pro C18 250 x 4.6 mm.
References
[1] Patent: EP1666463, 2006, A1. Location in patent: Page/Page column 9-10
4-methyl-7-nitro-1H-indole-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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