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COMBRETASTATIN A1

Product Name
COMBRETASTATIN A1
CAS No.
109971-63-3
Chemical Name
COMBRETASTATIN A1
Synonyms
COMBRETASTATIN A1;(Z)-3',4,4',5'-Tetramethoxystilbene-2,3-diol;(Z)-3,4,4',5-Tetramethoxy-2',3'-dihydroxystilbene;(Z)-3-Methoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol;3-Methoxy-6-[(Z)-3,4,5-trimethoxystyryl]-1,2-benzenediol;3-methoxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol;1,2-Benzenediol, 3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-;Combretastatin A1( 3-Methoxy-6-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-benzene-1,2-diol )
CBNumber
CB1251810
Molecular Formula
C18H20O6
Formula Weight
332.35
MOL File
109971-63-3.mol
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COMBRETASTATIN A1 Property

Melting point:
113-115 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
Boiling point:
528.4±50.0 °C(Predicted)
Density 
1.251±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 3 mg/ml
form 
A crystalline solid
pka
8.89±0.45(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19750
Product name
Combretastatin A1
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
19750
Product name
Combretastatin A1
Purity
≥98%
Packaging
10mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
19750
Product name
Combretastatin A1
Purity
≥98%
Packaging
25mg
Price
$311
Updated
2024/03/01
Cayman Chemical
Product number
19750
Product name
Combretastatin A1
Purity
≥98%
Packaging
50mg
Price
$538
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
TOX0000470
Product name
(Z)-3-METHOXY-6-(3,4,5-TRIMETHOXYSTYRYL)BENZENE-1,2-DIOL
Purity
95.00%
Packaging
5MG
Price
$504.21
Updated
2021/12/16
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COMBRETASTATIN A1 Chemical Properties,Usage,Production

Uses

Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects[1][2][3].

in vivo

Combretastatin A-1 (1-4 mg/kg; i.v. every other day for 4 weeks) significantly reduces the tumor volume in HepG2 subcutaneous xenograft model[2].
Combretastatin A-1 (2 mg/kg; every other day for 21 days) shows enhanced apoptosis in orthotopic hepatocellular carcinoma mouse model[2].

Animal Model:Male athymic BALB/c nu/nu mice (16-18 g; 4-6 weeks old) were inoculated with HepG2 cells[2]
Dosage:1, 2, 4?mg/kg
Administration:I.v. every other day for 4 weeks
Result:Resulted in a significant tumor volume reduction at the dose of 2?mg/kg or 4?mg/kg.

References

[1] Pettit GR, et, al. Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. J Nat Prod. Jan-Feb 1987;50(1):119-31. DOI:10.1021/np50049a016
[2] Mao J, et, al. Combretastatin A-1 phosphate, a microtubule inhibitor, acts on both hepatocellular carcinoma cells and tumor-associated macrophages by inhibiting the Wnt/β-catenin pathway. Cancer Lett. 2016 Sep 28;380(1):134-43. DOI:10.1016/j.canlet.2016.06.020
[3] Holwell SE, et, al. Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate. Anticancer Res. Nov-Dec 2002;22(6C):3933-40. PMID:12553015

COMBRETASTATIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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COMBRETASTATIN A1 Suppliers

China 27 Germany 3 United States 5 Global 35
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30

109971-63-3, COMBRETASTATIN A1Related Search:

Combretastatin A4 phosphate disodium salt COMBRETASTATIN A-4 (Z)-3-Ethoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol COMBRETASTATIN A1 cis Resveratrol combretastatin A-2 (R)-(-)-Combretastatin,COMBRETASTATIN Combretastatin D2 combretastatin B-1 Combretastatin D1 Combretastatin A-3 Combretastatin A-1 di-O-phosphate tetra-sodium salt (E)- Combretastatin A4 combretastatin B-3 combretastatin B-4 combretastatin A5 TETRASODIUM COMBRETASTATIN A1 2',3'-O-DIPHOSPHATE COMBRETASTATIN A4

  • 3-methoxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol
  • COMBRETASTATIN A1
  • (Z)-3,4,4',5-Tetramethoxy-2',3'-dihydroxystilbene
  • (Z)-3',4,4',5'-Tetramethoxystilbene-2,3-diol
  • 3-Methoxy-6-[(Z)-3,4,5-trimethoxystyryl]-1,2-benzenediol
  • (Z)-3-Methoxy-6-(3,4,5-Trimethoxystyryl)Benzene-1,2-Diol
  • Combretastatin A1( 3-Methoxy-6-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-benzene-1,2-diol )
  • 1,2-Benzenediol, 3-methoxy-6-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
  • 109971-63-3
  • Combretastatin