3-bromo-5-methoxyaniline
- Product Name
- 3-bromo-5-methoxyaniline
- CAS No.
- 16618-68-1
- Chemical Name
- 3-bromo-5-methoxyaniline
- Synonyms
- 3-bromo-5-methoxyaniline;3-Bromo-5-methoxyaniline 98%;3-bromo-5-methoxybenzenamine;3-BroMo-5-Methoxy-phenylaMine;3-broMo-5-MethoxyaMinobenzene;3-Bromo-5-methyloxybenzenamine;BenzenaMine, 3-broMo-5-Methoxy-;3-Amino-5-bromoanisole, 5-Bromo-m-anisidine
- CBNumber
- CB12518470
- Molecular Formula
- C7H8BrNO
- Formula Weight
- 202.05
- MOL File
- 16618-68-1.mol
3-bromo-5-methoxyaniline Property
- Melting point:
- 52-55°
- Boiling point:
- 285.8±20.0℃ (760 Torr)
- Density
- 1.531±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 126.7±21.8℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.10±0.10(Predicted)
- form
- powder
- color
- Very dark brown
Safety
- HS Code
- 2922290090
N-Bromosuccinimide Price
- Product number
- B700435
- Product name
- 3-Bromo-5-methoxyaniline
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 043524
- Product name
- 3-Bromo-5-methoxyaniline
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 043524
- Product name
- 3-Bromo-5-methoxyaniline
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR40401
- Product name
- 3-Bromo-5-methoxyaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 043524
- Product name
- 3-Bromo-5-methoxyaniline
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
3-bromo-5-methoxyaniline Chemical Properties,Usage,Production
Synthesis
16618-67-0
16618-68-1
General procedure for the synthesis of 3-bromo-5-methoxyaniline from 3-bromo-5-nitroanisole: 1. 30.0 g of 3,5-dinitrobenzene (0.18 mol) was dissolved in 180 mL of concentrated sulfuric acid and heated to 80 °C, maintaining the temperature between 80-90 °C. 44.5 g of N-bromosuccinimide (NBS, 0.25 mol) was added to the above solution in 9 batches and the reaction lasted for 30 min. After cooling, the reaction mixture was poured into 600 mL of ice water and a white precipitate was separated, which was filtered, washed and dried to give 41.3 g of white solid 3,5-dinitrobromobenzene in 93.7% yield. 2. Preparation of sodium solution in methanol: 1 g of sodium (43.4 mmol) was dissolved in methanol. Add 8.7 g of 3,5-dinitrobromobenzene (35.2 mmol) to the above sodium methanol solution, and reflux the reaction at 45°C for 2 hours. After cooling to room temperature, it was treated with 50 mL of 1N hydrochloric acid solution and then extracted with dichloromethane. The organic phases were combined, washed 3 times with saturated brine, dried over anhydrous magnesium sulfate, filtered and the solvent evaporated. The crude product was separated by column chromatography (petroleum ether:dichloromethane=5:1) to give 4.6g of 3-methoxy-5-nitrobromobenzene as a white powdery solid in 56.3% yield. 3. 2.32 g of 3-methoxy-5-nitrobromobenzene (10 mmol) was dissolved in 25 mL of methanol, 400 mg of Pd/C catalyst and 10 mL of acetone solution were added, and the reaction was carried out by passing hydrogen for 3 hours at room temperature. After completion of the reaction, the Pd/C was removed by filtration and the solvent was evaporated. The crude product was separated by column chromatography (petroleum ether:ethyl acetate=4:1) to give 1.95 g of 3-bromo-5-methoxyaniline as a light yellow solid in 96.5% yield.
References
[1] Patent: CN103497211, 2016, B. Location in patent: Paragraph 0074; 0075
[2] Patent: US2007/123527, 2007, A1. Location in patent: Page/Page column 79
[3] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0788
[4] Organic Letters, 2016, vol. 18, # 11, p. 2774 - 2776
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4889 - 4905
3-bromo-5-methoxyaniline Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-bromo-5-methoxyaniline manufacturers
- Product
- 3-bromo-5-methoxyaniline 16618-68-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-10-21
- Product
- 3-bromo-5-methoxyaniline 16618-68-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- JD724
- Release date
- 2019-09-02