ChemicalBook > CAS DataBase List > (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol

(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol

Product Name
(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
CAS No.
362512-81-0
Chemical Name
(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
Synonyms
TCIM;TC 1;(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol;2,6,3,5-Ethanediylidenepentaleno[1,6-bc]pyrrol-2(1H)-ol, 1-[2-(3-fluorophenyl)ethyl]octahydro-
CBNumber
CB12518748
Molecular Formula
C19H20FNO
Formula Weight
297.3666032
MOL File
362512-81-0.mol
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(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol Property

Melting point:
159-160 °C
Boiling point:
413.7±30.0 °C(Predicted)
Density 
1.462±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
Soluble to 50 mM in DMSO with gentle warming and to 50 mM in ethanol with gentle warming
form 
Powder
pka
13.82±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2669
Product name
TC1
Purity
≥99%(HPLC)
Packaging
10
Price
$225
Updated
2021/12/16
Tocris
Product number
2669
Product name
TC1
Purity
≥99%(HPLC)
Packaging
50
Price
$943
Updated
2021/12/16
TRC
Product number
T127530
Product name
TC1
Packaging
10mg
Price
$210
Updated
2021/12/16
Usbiological
Product number
256818
Product name
TC 1
Packaging
10mg
Price
$480
Updated
2021/12/16
ApexBio Technology
Product number
B7148
Product name
TC1
Packaging
10mg
Price
$339
Updated
2021/12/16
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(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol Chemical Properties,Usage,Production

Uses

TC 1 is a novel σ-receptor ligand derived from 4-azahexacyclo [5.4.1.02,6.03,10.05,9.08,11]dodecane, which modulates amphetamine-stimulated [3H] dopamine release.

Definition

ChEBI: LSM-1328 is a sesquiterpenoid.

in vivo

σ1 Receptor antagonist 4 (compound TC1; 3-100 mg/kg; ip; once) attenuats the stimulatory locomotor effect of 20 mg/kg Cocaine with a half-maximal depressant activity (ID50) of 38.6 mg/kg[1].

Animal Model:Male Swiss-Webster mice (Hsd:ND4, aged 2-3 month) injected with Cocaine[1]
Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg, 100 mg/kg
Administration:i.p.; once
Result:Attenuated the stimulatory locomotor effect of 20 mg/kg Cocaine.

IC 50

σ1R: 10 nM (Ki); σ2: 370 nM (Ki)

(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol Suppliers

China 37 United Kingdom 1 United States 6 USA 1 Global 45
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362512-81-0, (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-olRelated Search:


  • (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol
  • TC 1
  • 2,6,3,5-Ethanediylidenepentaleno[1,6-bc]pyrrol-2(1H)-ol, 1-[2-(3-fluorophenyl)ethyl]octahydro-
  • TCIM
  • 362512-81-0