ChemicalBook > CAS DataBase List > 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate

3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate

Product Name
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate
CAS No.
141064-23-5
Chemical Name
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate
Synonyms
Lumeron;LY246708 oxalate;Xanomeline oxalate;Xanomeline oxalate salt;LY246708;MEMCOR;LUMERON;Xanomeline oxalate (LY246708;Xanomeline oxalate, 10 mM in DMSO;Xanomeline oxalate, M1 muscarinic acetylcholine receptor agonist;Xanomeline oxalate, M1 muscarinic acetylcholine receptor agonist (DMSO solution);3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine oxalate
CBNumber
CB12518809
Molecular Formula
C14H23N3OS.C2H2O4
Formula Weight
371
MOL File
141064-23-5.mol
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3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate Property

Melting point:
148-150℃
storage temp. 
Desiccate at +4°C
solubility 
DMF: 1.6 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05816
Product name
Xanomeline Oxalate - CAS 141064-23-5 - Calbiochem
Packaging
10mg
Price
$187
Updated
2025/07/31
Cayman Chemical
Product number
10790
Product name
Xanomeline oxalate
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
10790
Product name
Xanomeline oxalate
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
10790
Product name
Xanomeline oxalate
Purity
≥98%
Packaging
10mg
Price
$160
Updated
2024/03/01
Tocris
Product number
3569
Product name
Xanomelineoxalate
Purity
≥98%(HPLC)
Packaging
10
Price
$195
Updated
2021/12/16
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3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate Chemical Properties,Usage,Production

Description

Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Xanomeline (oxalate) is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively). It has antipsychotic-like activities in rats and Cebus monkeys. M1 selective agonists, like Xanomeline (oxalate), enhance memory function and has utility in treating Alzheimer’s Disease.

Uses

Xanomeline oxalate is a functionally selective mAChR M1 agonist.

in vivo

Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 8.1 μmole/kg in hippocampus[1].

Animal Model:Male CF1 mice weighing 18-20 g are injected [3H]-myoinositol[1]
Dosage:8.1-81 μmole/kg
Administration:S.c. injections; 1 h prior to killing and 1 h after the administration
Result:Increased accumulation in a dose-related manner up to 130%, 75%, 60% above lithium levels in hippocampus, cortex and neostriatum, respectively. And did not increase accumulation of [3H]-IP in the brain stem. Induced salivation, tremor and hypothermia in mice with the ED50 of 13.7±0.8 μmole/kg.
Animal Model:Rats are injected [3H]-myoinositol[1]
Dosage:2.7-81 μmole/kg
Administration:S.c. injections; 1 h prior to killing and 1 h after the administration
Result:Increased [3H]-IP formation dose dependently in hippocampus up to 221% above lithium control.

storage

Desiccate at +4°C

References

[1] JULIA N. HEINRICH . Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists[J]. European journal of pharmacology, 2009, 605 1: Pages 53-56. DOI: 10.1016/j.ejphar.2008.12.044
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] MAIBRITT B ANDERSEN. The Muscarinic M1/M4 Receptor Agonist Xanomeline Exhibits Antipsychotic-Like Activity in Cebus apella Monkeys[J]. Neuropsychopharmacology, 2003, 28 6: 1168-1175. DOI: 10.1038/sj.npp.1300151
[4] MESSER W S. The utility of muscarinic agonists in the treatment of alzheimer’s disease[J]. Journal of Molecular Neuroscience, 2002, 19 1-2: 187-193. DOI: 10.1007/s12031-002-0031-5

3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate Suppliers

China 79 India 2 United Kingdom 4 United States 12 Global 97
3B Pharmachem (Wuhan) International Co.,Ltd.
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LETOPHARM LIMITED
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View Lastest Price from 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate 141064-23-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-17

141064-23-5, 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalateRelated Search:

Xanomeline metabolite C 2,3,4,5-tetrahydrobenzo[b]oxepin-4-amine

  • 3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine oxalate
  • Lumeron
  • LY246708;MEMCOR;LUMERON
  • 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine ethanedioate (1:1)
  • 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate
  • Xanomeline oxalate
  • LY246708 oxalate
  • Xanomeline oxalate salt
  • Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-, ethanedioate (1:1)
  • 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole oxalate
  • Xanomeline oxalate, M1 muscarinic acetylcholine receptor agonist (DMSO solution)
  • Xanomeline oxalate, M1 muscarinic acetylcholine receptor agonist
  • Xanomeline oxalate, 10 mM in DMSO
  • Xanomeline oxalate (LY246708
  • 141064-23-5
  • C14H23N3OSC2H2O4
  • C2H2O4C14H23N3OS
  • 1