4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

Product Name: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride
CAS No.: 388575-52-8
Chemical Name: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride
Synonyms: PSN375963;PSN 375963 hydrochloride;5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole;4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine;Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-;4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride;Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP
CBNumber: CB12518900
Molecular Formula: C17H23N3O
Formula Weight: 285.38
MOL File: 388575-52-8.mol

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4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Property

Boiling point:: 440.1±47.0 °C(Predicted)
Density: 1.060±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10mg/mL
form: powder
pka: 0.82±0.10(Predicted)
color: white to off-white

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Safety

WGK Germany: nwg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0028
Product name: PSN-375963
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $358
Updated: 2022/05/15

Cayman Chemical

Product number: 10008593
Product name: PSN375963
Purity: ≥98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 10008593
Product name: PSN375963
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10008593
Product name: PSN375963
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 10008593
Product name: PSN375963
Purity: ≥98%
Packaging: 25mg
Price: $278
Updated: 2024/03/01

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4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Chemical Properties,Usage,Production

Biochem/physiol Actions

PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Suppliers

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388575-52-8, 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochlorideRelated Search:

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

PSN 375963 hydrochloride

PSN375963

4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine

5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole

Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP

Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-

388575-52-8

C17H23N3OHCl