1-(4-Methoxy-benzyl)-piperidine-2,4-dione
- Product Name
- 1-(4-Methoxy-benzyl)-piperidine-2,4-dione
- CAS No.
- 712353-75-8
- Chemical Name
- 1-(4-Methoxy-benzyl)-piperidine-2,4-dione
- Synonyms
- 1-(4-Methoxybenzyl)-2,4-piperidinedione;1-(4-Methoxy-benzyl)-piperidine-2,4-dione;1-[(4-Methoxyphenyl)Methyl]piperidine-2,4-dione;2,4-Piperidinedione, 1-[(4-methoxyphenyl)methyl]-
- CBNumber
- CB12520129
- Molecular Formula
- C13H15NO3
- Formula Weight
- 233.26
- MOL File
- 712353-75-8.mol
1-(4-Methoxy-benzyl)-piperidine-2,4-dione Property
- Boiling point:
- 417.5±40.0 °C(Predicted)
- Density
- 1.209±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 7.78±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AK119581
- Product name
- 1-(4-Methoxybenzyl)piperidine-2,4-dione
- Purity
- 95%
- Packaging
- 100mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- AK119581
- Product name
- 1-(4-Methoxybenzyl)piperidine-2,4-dione
- Purity
- 95%
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- CHM0386823
- Product name
- 1-(4-METHOXYBENZYL)PIPERIDINE-2,4-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.88
- Updated
- 2021/12/16
- Product number
- 126789
- Product name
- 1-(4-Methoxybenzyl)piperidine-2,4-dione
- Purity
- >95%
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- 1055AC
- Product name
- 1-(4-Methoxybenzyl)piperidine-2,4-dione
- Packaging
- 1g
- Price
- $188
- Updated
- 2021/12/16
1-(4-Methoxy-benzyl)-piperidine-2,4-dione Chemical Properties,Usage,Production
Synthesis
712353-74-7
712353-75-8
A mixture of aqueous potassium carbonate (K2CO3, 3.2 g, 23.2 mmol, 5 eq.) and 18-crown-6 (purified by azeotropy with toluene, 122 mg, 0.446 mmol, 10 mol%) in anhydrous toluene (4 mL) was heated to reflux under nitrogen protection. Subsequently, a toluene solution of N-(4-methoxybenzyl)-N-(2-methoxycarbonylethyl)maleic acid methyl ester was added dropwise over 40 min. After the reflux reaction for 7 h, the reaction mixture was diluted with water (4 mL) and toluene (4 mL), cooled to 0°C and carefully acidified with 0.1 N hydrochloric acid to pH 1.7. Next, the mixture was extracted several times with dichloromethane (CH2Cl2, 3 x 80 mL), the organic phases were combined, dried, and then concentrated to give a brown oil (1.33 g). The oily substance was treated with 10% aqueous oxalic acid solution and heated to reflux for 6.5 hours. After the completion of the reaction, it was again extracted with dichloromethane (CH2Cl2) several times, and the organic phases were combined, dried and concentrated to obtain a light yellow oily crude product (1.03 g). The crude product was purified by silica gel column chromatography using a solvent mixture of dichloromethane and methanol (CH2Cl2:MeOH = 30:1) as eluent to afford 1-(4-methoxybenzyl)piperidine-2,4-dione as a light brown solid (750 mg, 69% yield). The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 2.52 (t, J = 5.7 Hz, 2H), 3.41 (s, 2H), 3.47 (t, J = 5.7 Hz, 2H), 3.80 (s, 3H), 4.62 (s, 2H), 6.16-6.88 (m, 2H), 7.20 (m, 2H).
References
[1] Patent: WO2004/52885, 2004, A1. Location in patent: Page 130-132
1-(4-Methoxy-benzyl)-piperidine-2,4-dione Preparation Products And Raw materials
Raw materials
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