5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid
- Product Name
- 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid
- CAS No.
- 1204298-65-6
- Chemical Name
- 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid
- Synonyms
- Fluxapyroxad Impurity 3;5-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid;5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 5-(difluoroMethyl)-1-Methyl-
- CBNumber
- CB12520220
- Molecular Formula
- C6H6F2N2O2
- Formula Weight
- 176.12
- MOL File
- 1204298-65-6.mol
5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid Property
- Boiling point:
- 315.9±42.0 °C(Predicted)
- Density
- 1.52
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.12±0.36(Predicted)
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D445348
- Product name
- 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylicAcid
- Packaging
- 50mg
- Price
- $695
- Updated
- 2021/12/16
- Product number
- PC910578
- Product name
- 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- PC910578
- Product name
- 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $470
- Updated
- 2021/12/16
- Product number
- 3543AA
- Product name
- 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylicacid
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
- Product number
- HCH0054114
- Product name
- 5-(DIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid Chemical Properties,Usage,Production
Uses
5-(Difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid is a useful reagent in the preparation of fluxapyroxad analogs which are anti-fungal agents.
Synthesis
851725-87-6
176969-34-9
1204298-65-6
The general procedure for the synthesis of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid and 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid using ethyl 3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylate as a raw material was as follows: according to the method of Example 13, 200 g of 3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (GC purity: 92.8%, 0.783 mol) was added to an autoclave with 69.50 g of 1,3-dimethyl-2-imidazolidinone hexadecyl hydrofluoric acid salt (0.160 mol). The temperature was gradually increased to 130°C to 155°C. When the system temperature reached 130 to 155°C, the reaction was maintained at this temperature range for 7 to 12 hours. Upon completion of the reaction, the pressure was released, purged with nitrogen, and the exhaust gas was treated by alkaline absorption. The reaction mixture was cooled to 60 to 80°C and the reaction solution was diluted by adding 350 g of xylene and 60 g of water. Subsequently, 125.00 g of aqueous sodium hydroxide solution with a mass concentration of 30% (mass concentration refers to the percentage of sodium hydroxide to the total mass of the solution) was slowly added dropwise and stirred at 70°C for 1 hour. The mixture was separated and the aqueous phase was acidified with concentrated hydrochloric acid at a mass concentration of 36% (mass concentration refers to the percentage of hydrogen chloride to the total mass of the concentrated hydrochloric acid) to pH=1.0. Cooled to 10-25°C, filtered and dried under vacuum to give 117.60 g of 3-(difluoromethyl)-1 -methyl-1H-pyrazole-4-carboxylic acid (Yield: 84.5%, HPLC purity: 99.1%; isomer 5 -(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid with HPLC purity of 0.05%).
References
[1] Patent: CN106467492, 2017, A. Location in patent: Paragraph 0224; 0225; 0226; 0227; 0228; 0229; 0230-0235
5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid Suppliers
- Tel
- 17321241880
- 485229790@qq.com
- Country
- China
- ProdList
- 1750
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 0731-88827538 15873153880
- Fax
- 0731-88827238
- luxingbc@126.com
- Country
- China
- ProdList
- 2001
- Advantage
- 65
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12000
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 15902830537
- zhanghao@happysyn.com
- Country
- China
- ProdList
- 3180
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4877
- Advantage
- 58
- Tel
- 15088289376
- 248775804@qq.com
- Country
- China
- ProdList
- 4995
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +8615604608665 15604608665
- dominicguo@gk-bio.com
- Country
- CHINA
- ProdList
- 9414
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15109
- Advantage
- 58
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3609
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29798
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- +86-13522808617
- omichem@126.com
- Country
- China
- ProdList
- 6413
- Advantage
- 58
- Tel
- 17712623939
- sales@hongdesciences.com
- Country
- China
- ProdList
- 326
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 18721109360
- 306685371@qq.com
- Country
- China
- ProdList
- 1944
- Advantage
- 58
- Tel
- 18661161657
- yaoxiangqiu2021@163.com
- Country
- China
- ProdList
- 9968
- Advantage
- 58
- Tel
- 4000255188
- Fax
- 025 86918232
- sales_china@pharmablock.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39665
- Advantage
- 58
- Tel
- 021-021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29784
- Advantage
- 58
- Tel
- 0573-85866609 13588473046
- 824930988@qq.com
- Country
- China
- ProdList
- 7865
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27987
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 18162595016; 18162595016
- 3287908757@qq.com
- Country
- China
- ProdList
- 9119
- Advantage
- 58
- Tel
- 16621224781
- syy@titansci.com
- Country
- China
- ProdList
- 2896
- Advantage
- 58
- Tel
- 15620920485; 15620920485
- 823251269@qq.com
- Country
- China
- ProdList
- 1266
- Advantage
- 58
- Tel
- 15890142075
- 3555133855@qq.com
- Country
- China
- ProdList
- 9853
- Advantage
- 58
- Tel
- 021-57540919 13120888836
- lily@yhp-biomedicine.com
- Country
- China
- ProdList
- 8257
- Advantage
- 58
- Tel
- +86-16631818819 +86-17736933208
- 3684455296@qq.com
- Country
- China
- ProdList
- 9300
- Advantage
- 58
- Tel
- +86-512-68323658 +86-18168183658
- sales1@artkmedchem.com
- Country
- China
- ProdList
- 39002
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ideaworkspharm.com
- Country
- China
- ProdList
- 243
- Advantage
- 58
- Tel
- --
- Fax
- --
- liujh@hi2000.com
- Country
- China
- ProdList
- 206
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- yiji01@foxmail.com
- Country
- China
- ProdList
- 6021
- Advantage
- 50
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6800
- Advantage
- 58
View Lastest Price from 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid manufacturers
- Product
- 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid 1204298-65-6
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02