ChemicalBook > CAS DataBase List > methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate

methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate

Product Name
methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate
CAS No.
959585-44-5
Chemical Name
methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate
Synonyms
-1H-pyrazole-1-acetate;1-(2-Methoxy-2-oxoethyl)pyrazole-4-boronic Acid Pinacol Ester;methyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyr...;(1-(2-METHOXY-2-OXOETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;Methyl 2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetate;Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate;methyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetate;methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate;Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate - [M26936];1H-Pyrazole-1-acetic acid, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester
CBNumber
CB12520260
Molecular Formula
C12H19BN2O4
Formula Weight
266.1
MOL File
959585-44-5.mol
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methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M329263
Product name
1-(Methoxycarbonylmethyl)pyrazole-4-boronicacidpinacolester
Packaging
100mg
Price
$165
Updated
2021/12/16
Synthonix
Product number
M26936
Product name
Methyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate
Purity
97%
Packaging
1g
Price
$210
Updated
2021/12/16
AK Scientific
Product number
6701AC
Product name
Methyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate
Packaging
250mg
Price
$221
Updated
2021/12/16
Synthonix
Product number
M26936
Product name
Methyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate
Purity
97%
Packaging
100mg
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
094582
Product name
Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate
Purity
95+%
Packaging
250mg
Price
$364
Updated
2021/12/16
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methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Chemical Properties,Usage,Production

Synthesis

269410-08-4

96-32-2

959585-44-5

To a solution of N,N-dimethylformamide (DMF, 52 mL) of pinacol ester of 4-pyrazoleboronic acid (5.0 g, 25.8 mmol) was added cesium carbonate (Cs2CO3, 8.396 g, 25.8 mmol) and methyl bromoacetate (2.52 mL, 25.8 mmol). The reaction mixture was stirred at 90 °C under nitrogen protection overnight. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water three times, brine once and dried over anhydrous sodium sulfate (Na2SO4). The organic phase was concentrated under reduced pressure to afford methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetate (4.27 g, 62% yield).

References

[1] Patent: WO2007/138472, 2007, A2. Location in patent: Page/Page column 32
[2] Patent: WO2014/1802, 2014, A1. Location in patent: Page/Page column 42; 43
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 - 6363
[4] Patent: US2012/115861, 2012, A1. Location in patent: Page/Page column 22

methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate Suppliers

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959585-44-5, methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetateRelated Search:


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  • (1-(2-METHOXY-2-OXOETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
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  • 959585-44-5