4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine
- Product Name
- 4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine
- CAS No.
- 63894-67-7
- Chemical Name
- 4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine
- Synonyms
- 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl);4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine;4-(2-chlorothiophen[2,3-d]pyrimidin-4-yl)morpholine;Thieno[2,3-d]pyriMidine, 2-chloro-4-(4-Morpholinyl)-;4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine ISO 9001：2015 REACH
- CBNumber
- CB12526242
- Molecular Formula
- C10H10ClN3OS
- Formula Weight
- 255.72
- MOL File
- 63894-67-7.mol
4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
N-Bromosuccinimide Price
- Product number
- FC143776
- Product name
- 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine
- Packaging
- 250mg
- Price
- $67.5
- Updated
- 2021/12/16
- Product number
- FC143776
- Product name
- 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine
- Packaging
- 1g
- Price
- $201
- Updated
- 2021/12/16
- Product number
- HCH0365150
- Product name
- 4-(2-CHLOROTHIENO[2,3-D]PYRIMIDIN-4-YL)MORPHOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $240.45
- Updated
- 2021/12/16
- Product number
- FC143776
- Product name
- 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine
- Packaging
- 2g
- Price
- $349
- Updated
- 2021/12/16
- Product number
- FC143776
- Product name
- 4-(2-Chlorothieno[2,3-d]pyrimidin-4-yl)morpholine
- Packaging
- 5G
- Price
- $697.5
- Updated
- 2021/12/16
4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine Chemical Properties,Usage,Production
Synthesis
110-91-8
18740-39-1
63894-67-7
General procedure for the synthesis of 2-chloro-4-morpholinothieno[2,3-d]pyrimidines from morpholine and 2,4-dichlorothieno[2,3-d]pyrimidines: a 5L three-necked flask was assembled with a mechanical stirrer, an internal temperature probe, and nitrogen bubbling device, and 2,4-dichlorothieno[2,3-d]pyrimidines (91 g) and methanol (1.5 L) were added. Subsequently, morpholine (85.1 g) was added to the reaction system and the reaction mixture was stirred at room temperature for 1-2 hours. During the reaction, a small amount of the reaction solution was taken and diluted with dichloromethane/acetonitrile (DCM/ACN) and analyzed by LC/MS to monitor the consumption of raw materials. Upon completion of the reaction, water (3.0 L) was added to the reaction flask and the internal temperature was controlled to be below 25 °C. The resulting solid product was collected by vacuum filtration and washed with 500 mL of water. The washed solid was placed in a vacuum oven and dried at 66 °C for 24 h to obtain the target product 2-chloro-4-morpholinothieno[2,3-d]pyrimidine. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ3.736 (t, J=4.8 Hz, 4H), δ3.897 (t, J=5.2 Hz, 4H), δ7.658 (d, J=6.4 Hz, 1H), δ7.682 (t, J=6.4 Hz, 4H). lcms (ESI pos) m/e 257 (M+1).
References
[1] Patent: WO2008/73785, 2008, A2. Location in patent: Page/Page column 170
[2] European Journal of Medicinal Chemistry, 2015, vol. 93, p. 64 - 73
[3] Patent: CN106831812, 2017, A. Location in patent: Paragraph 0094; 0095; 0096
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 22, p. 7815 - 7833
[5] Patent: CN103980287, 2016, B. Location in patent: Paragraph 0148; 0153; 0154
4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine Suppliers
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 0510-86010668
- Fax
- 0510-86010668
- sales@biopharmamatrix.com
- Country
- China
- ProdList
- 4740
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 0371-0371-61318675 17719817155
- Fax
- 0371-61318675
- sales@xlinebio.com
- Country
- China
- ProdList
- 2857
- Advantage
- 58
View Lastest Price from 4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine manufacturers
- Product
- 4-(2-chlorothieno[2,3-d]pyriMidin-4-yl)Morpholine 63894-67-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25