methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE)
- Product Name
- methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE)
- CAS No.
- 850832-54-1
- Chemical Name
- methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE)
- Synonyms
- Methyl-4-broMo-5-Methyl-3-isoxazolecarboxylate;Methyl 4-bromo-5-methyl-1,2-oxazole-3-carboxylate;methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE)
- CBNumber
- CB12526752
- Molecular Formula
- C6H6BrNO3
- Formula Weight
- 220.02
- MOL File
- 850832-54-1.mol
methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE) Property
- Boiling point:
- 285.6±35.0 °C(Predicted)
- Density
- 1.620±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -7.03±0.50(Predicted)
- form
- solid
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CBR01808
- Product name
- Methyl 4-bromo-5-methyl-3-isoxazolecarboxylate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $497
- Updated
- 2025/07/31
- Product number
- M297015
- Product name
- Methyl4-bromo-5-methylisoxazole-3-carboxylate
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0061153
- Product name
- Methyl4-bromo-5-methyl-1,2-oxazole-3-carboxylate
- Packaging
- 5g
- Price
- $938
- Updated
- 2021/12/16
- Product number
- CS-0061153
- Product name
- Methyl4-bromo-5-methyl-1,2-oxazole-3-carboxylate
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 040824
- Product name
- Methyl 4-bromo-5-methylisoxazole-3-carboxylate
- Packaging
- 500mg
- Price
- $143
- Updated
- 2021/12/16
methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE) Chemical Properties,Usage,Production
Synthesis
19788-35-3
850832-54-1
General procedure for the synthesis of 4-bromo-5-methylisoxazole-3-carboxylic acid methyl ester from 5-methylisoxazole-3-carboxylic acid: bromine (49.4 g, 309 mmol) was slowly added dropwise to a solution of 5-methylisoxazole-3-carboxylic acid methyl ester (30 g, 206 mmol) dissolved in chloroform (103 mL) at room temperature. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into a mixture of saturated aqueous potassium carbonate solution and saturated aqueous sodium thiosulfate solution. It was extracted twice with chloroform and the organic layers were combined. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography with the eluent being petroleum ether: ethyl acetate (10:1, v/v) to afford methyl 4-bromo-5-methylisoxazole-3-carboxylate (27.3 g, 60% yield) as a white solid. Mass spectrometry (MS) data: 220/222 [M + H]+, APCI (methanol).
References
[1] Patent: WO2005/37271, 2005, A2. Location in patent: Page/Page column 185
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 18, p. 8337 - 8352
methyl 4-bromo-5-methyl-3-isoxazolecarboxylate(SALTDATA: FREE) Preparation Products And Raw materials
Raw materials
Preparation Products
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