1-Boc-2-isopropylhydrazine

Product Name: 1-Boc-2-isopropylhydrazine
CAS No.: 16689-35-3
Chemical Name: 1-Boc-2-isopropylhydrazine
Synonyms: 1-Boc-2-isopropylhydrazine;tert-Butyl 3-(Isopropyl)carbazate;tert-Butyl 3-(Isopropyl)carbazate >t-Butyl 2-isopropylhydrazinecarboxylate;tert-Butyl 3-(Isopropyl)carbazate;1-tert-Butoxycarbonyl-2-isopropylhydrazine;tert-Butyl 2-isopropylhydrazinecarboxylate;3-(Isopropyl)carbazic Acid tert-Butyl Ester;tert-butyl2-isopropylhydrazine-1-carboxylate;2-Isopropylhydrazinecarboxylic acid tert-butyl ester
CBNumber: CB12533921
Molecular Formula: C8H18N2O2
Formula Weight: 174.24
MOL File: 16689-35-3.mol

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1-Boc-2-isopropylhydrazine Property

Melting point:: 47-51℃
Boiling point:: 80°C/0.6mmHg(lit.)
Density: 0.956
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white
CAS DataBase Reference: 16689-35-3

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Safety

HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4375
Product name: tert-Butyl 3-(Isopropyl)carbazate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: B4375
Product name: tert-Butyl 3-(Isopropyl)carbazate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $184
Updated: 2024/03/01

TRC

Product number: B694620
Product name: tert-Butyl2-Isopropylhydrazinecarboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140025
Product name: tert-Butyl 2-isopropylhydrazinecarboxylate
Packaging: 1g
Price: $40
Updated: 2021/12/16

Ark Pharm

Product number: AK-83246
Product name: tert-Butyl2-isopropylhydrazinecarboxylate
Purity: 95%
Packaging: 250mg
Price: $11
Updated: 2021/12/16

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1-Boc-2-isopropylhydrazine Chemical Properties,Usage,Production

Synthesis

16689-34-2

16689-35-3

General procedure for the synthesis of 1-Boc-2-isopropylhydrazine from tert-butyl 2-(propan-2-ylidene)hydrazinecarboxylate: tert-butyl 2-(propan-2-ylidene)hydrazinecarboxylate (0.51 g, 3.0 mmol) was dissolved in 20 mL of tetrahydrofuran (THF), sodium cyanoborohydride (NaBH3CN, 0.19 g, 3.0 mmol) and a small amount of bromocresol green was added as the indicator. Subsequently, 1.5 mL of THF solution of p-toluenesulfonic acid (0.57 g, 3.0 mmol) was added slowly and dropwise over about 1 hour, maintaining the pH of the reaction system between 3.5 and 5.0. The reaction mixture was continued to be stirred at room temperature for 1 h before the solvent was removed by rotary evaporation. The residue was extracted by partitioning with ethyl acetate (30 mL) and saturated saline. The organic phase was washed sequentially with saturated sodium bicarbonate solution (20 mL) and saturated saline, and then evaporated to dryness. The obtained residue was dissolved in 10 mL of ethanol, 3.6 mL of 1M sodium hydroxide solution (3.6 mmol) was added and stirred at room temperature for 30 min. After completion of the reaction, the solvent was removed by rotary evaporation and the residue was dissolved in ethyl acetate and extracted with water. The organic layer was evaporated under reduced pressure and the residue was purified by column chromatography to afford tert-butyl 2-isopropylhydrazinecarboxylate (0.4 g, 77% yield) using a dichloromethane solution of 5% methanol as eluent. The product characterization data were as follows: melting point 47-49 °C; thin layer chromatography Rf=0.44 (dichloromethane solution of 5% methanol); 1H NMR (300 MHz, CDCl3) δ 6.03 (s, 1H, NH), 3.92 (s, 1H, NH), 3.14 (m, 1H), 1.46 (s, 9H), 1.02 (d, 6H, J=6 Hz); 13C NMR (300 MHz, CDCl3) δ 157.2, 80.8, 51.2, 28.7, 21.0.

References

[1] Polish Journal of Chemistry, 2002, vol. 76, # 12, p. 1693 - 1697
[2] Journal of the American Chemical Society, 2004, vol. 126, # 21, p. 6759 - 6764
[3] Patent: WO2014/140073, 2014, A1. Location in patent: Page/Page column 24
[4] Chemistry - A European Journal, 2018, vol. 24, # 33, p. 8325 - 8330
[5] Patent: WO2004/56751, 2004, A1. Location in patent: Page 18-19

1-Boc-2-isopropylhydrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-2-isopropylhydrazine Suppliers

Americas 1 Belgium 1 Canada 1 China 75 Europe 1 Germany 1 India 6 Japan 3 United Kingdom 4 United States 21 Global 114

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16689-35-3, 1-Boc-2-isopropylhydrazineRelated Search:

Cumene

1-Boc-2-isopropylhydrazine

2-Isopropylhydrazinecarboxylic acid tert-butyl ester

tert-Butyl 2-isopropylhydrazinecarboxylate

tert-Butyl 3-(Isopropyl)carbazate

t-Butyl 2-isopropylhydrazinecarboxylate

<i>tert</i>-Butyl 3-(Isopropyl)carbazate

tert-butyl2-isopropylhydrazine-1-carboxylate

Hydrazinecarboxylic acid, 2-(1-methylethyl)-, 1,1-dimethylethyl ester

N-Isopropyl-Hydrazinecarboxylic Acid Tert-Butyl Ester

tert-Butyl 3-(Isopropyl)carbazate &gt

1-tert-Butoxycarbonyl-2-isopropylhydrazine

3-(Isopropyl)carbazic Acid tert-Butyl Ester

Hydrazinecarboxylic acid, 2-(1-methylethyl)-, 1,1-dimethylet...

16689-35-3

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