6-Bromo-2-methylpyridine-3-carboxaldehyde
- Product Name
- 6-Bromo-2-methylpyridine-3-carboxaldehyde
- CAS No.
- 926293-55-2
- Chemical Name
- 6-Bromo-2-methylpyridine-3-carboxaldehyde
- Synonyms
- KML-70;KML-102;CML-017;6-BroMo-2-Methylnicotinaldehyde;6-BroMo-2-Methyl-pyridine-3-carbaldehyde;6-bromo-2-methyl-3-Pyridinecarboxaldehyde;6-Bromo-2-methylpyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 6-bromo-2-methyl-
- CBNumber
- CB12534625
- Molecular Formula
- C7H6BrNO
- Formula Weight
- 200.03
- MOL File
- 926293-55-2.mol
6-Bromo-2-methylpyridine-3-carboxaldehyde Property
- Boiling point:
- 285℃
- Density
- 1.577
- Flash point:
- 126℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.29±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C7H6BrNO/c1-5-6(4-10)2-3-7(8)9-5/h2-4H,1H3
- InChIKey
- CUTAVXXGKKXAHQ-UHFFFAOYSA-N
- SMILES
- C1(C)=NC(Br)=CC=C1C=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B682223
- Product name
- 6-Bromo-2-methylnicotinaldehyde
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- HCH0367728
- Product name
- 6-BROMO-2-METHYLNICOTINALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.33
- Updated
- 2021/12/16
- Product number
- BB20-9150
- Product name
- 6-Bromo-2-methyl-pyridine-3-carbaldehyde
- Purity
- ＞97%
- Packaging
- 5G
- Price
- $665
- Updated
- 2021/12/16
- Product number
- 18546
- Product name
- 6-Bromo-2-methyl-pyridine-3-carbaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $668
- Updated
- 2021/12/16
- Product number
- 10-2804
- Product name
- 6-bromo-2-methylnicotinaldehyde
- Purity
- 95%-98%
- Packaging
- 1g
- Price
- $725
- Updated
- 2021/12/16
6-Bromo-2-methylpyridine-3-carboxaldehyde Chemical Properties,Usage,Production
Synthesis
39919-65-8
68-12-2
926293-55-2
General procedure for the synthesis of 6-bromo-2-methylnicotinic aldehyde from 2,5-dibromo-6-methylpyridine and N,N-dimethylformamide: To a solution of 3,6-dibromo-2-methylpyridine (60 g, 239 mmol) in tetrahydrofuran (THF, 600 mL) under nitrogen protection was slowly added at -78°C n-butyllithium (n-BuLi, 100 mL. 251 mmol). The reaction mixture was stirred continuously at -78 °C for 1 hour. Subsequently, N,N-dimethylformamide (DMF, 20.4 mL, 263 mmol) was added dropwise and stirring was continued at -78 °C for 1 hour. The reaction mixture was slowly warmed to 25 °C and the reaction was quenched by the addition of 1 M aqueous hydrochloric acid (300 mL). This reaction mixture was combined and processed with five other parallel reactions (30 g, 120 mmol and 4 x 50 g, 199 mmol of 3,6-dibromo-2-methylpyridine, respectively, maintaining the same reagent and solvent ratios). The combined reaction mixtures were extracted with ethyl acetate (EtOAc, 800 mL × 4), and the combined organic layers were washed with deionized water (H2O, 300 mL × 3), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product, 6-bromo-2-methylnicotinic aldehyde (260 g, 492 mmol, 42.5% combined yield), as a red oil The product was analyzed by NMR hydrogen spectroscopy. The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, chloroform-d): δ10.28 (s, 1H), 7.92 (d, J=7.9 Hz, 1H), 7.64 (s, 1H), 2.88-2.83 (m, 3H). Liquid chromatography-mass spectrometry (LCMS) analysis showed [M+H]+ peaks at m/z = 200.1 and 202.1.
References
[1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 51
[2] Patent: CN106608879, 2017, A. Location in patent: Paragraph 0310-0313
[3] Patent: WO2017/145050, 2017, A1. Location in patent: Page/Page column 25-26
6-Bromo-2-methylpyridine-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-Bromo-2-methylpyridine-3-carboxaldehyde manufacturers
- Product
- 6-Bromo-2-methylpyridine-3-carboxaldehyde 926293-55-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-30
- Product
- 6-Bromo-2-methylpyridine-3-carboxaldehyde 926293-55-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12