LRRK2-IN-1
- Product Name
- LRRK2-IN-1
- CAS No.
- 1234480-84-2
- Chemical Name
- LRRK2-IN-1
- Synonyms
- CS-642;NSC7001;NSC 7001;NSC-7001;LRRK2-TN-1;LRRK2-IN-1;LRRK2 inhibitor;LRRK2-IN-1 USP/EP/BP;LRRK2-IN-1; LRRK2 INHIBITOR;2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-
- CBNumber
- CB12534670
- Molecular Formula
- C31H38N8O3
- Formula Weight
- 570.69
- MOL File
- 1234480-84-2.mol
LRRK2-IN-1 Property
- Boiling point:
- 787.8±70.0 °C(Predicted)
- Density
- 1.278
- storage temp.
- Store at -20°C
- solubility
- ≥28.55 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
- form
- solid
- pka
- 8.14±0.42(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 438193
- Product name
- LRRK2-IN-1
- Purity
- LRRK2-IN-1 primarily used in Inhibition.
- Packaging
- 5MG
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 18094
- Product name
- LRRK2-IN-1
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 18094
- Product name
- LRRK2-IN-1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 18094
- Product name
- LRRK2-IN-1
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 4273
- Product name
- LRRK2-IN-1
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $292
- Updated
- 2021/12/16
LRRK2-IN-1 Chemical Properties,Usage,Production
Description
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson''s disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. LRRK2-IN-1 is a potent inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC50s = 13 and 6 nM, respectively). It is selective for LRRK2 over a large panel of other kinases. LRRK2-IN-1 treatment causes dephosphorylation of LRRK2, leading to its dissociation from 14-3-3 proteins, ubiquitination, and degradation. Inhibitors of LRRK2, including LRRK2-IN-1, stimulate macroautophagy in H4 neuroglioma cells.
Uses
LRRK2-IN-1 is a benzodiazepine based derivative and is known as a selective inhibitor of the Parkinson''s disease kinase LRRK2.
Definition
ChEBI: LRRK2-IN-1 is a member of the class of pyrimidobenzodiazepines that is 5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a 4-[(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-methoxyanilino substituent. It is an inhibitor of the Parkinson's disease kinase LRRK2. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is a N-acylpiperidine, a N-alkylpiperazine, an aromatic ether, a pyrimidobenzodiazepine, an aromatic amine, a secondary amino compound and a tertiary amino compound.
storage
Store at -20°C
LRRK2-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
LRRK2-IN-1 Suppliers
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View Lastest Price from LRRK2-IN-1 manufacturers
- Product
- LRRK2-IN-1 1234480-84-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23