ChemicalBook > CAS DataBase List > A 419259 trihydrochloride

A 419259 trihydrochloride

Product Name
A 419259 trihydrochloride
CAS No.
364042-47-7
Chemical Name
A 419259 trihydrochloride
Synonyms
RK20449;A419259;RK-20449;A 419259;RK 20449;A-419259;A-419259 HCl;A 419259 trihydrochloride;7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-
CBNumber
CB12535657
Molecular Formula
C29H34N6O
Formula Weight
482.62
MOL File
364042-47-7.mol
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A 419259 trihydrochloride Property

Boiling point:
686.4±55.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
H2O: soluble10mg/mL (clear solution)
pka
8.20±0.42(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0446
Product name
A-419259 trihydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$207
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0446
Product name
A-419259 trihydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$870
Updated
2024/03/01
Cayman Chemical
Product number
25605
Product name
A-419259
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
25605
Product name
A-419259
Purity
≥98%
Packaging
500μg
Price
$35
Updated
2021/12/16
Cayman Chemical
Product number
25605
Product name
A-419259
Purity
≥98%
Packaging
5mg
Price
$199
Updated
2024/03/01
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A 419259 trihydrochloride Chemical Properties,Usage,Production

Description

A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.

Uses

A 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.

A 419259 trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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A 419259 trihydrochloride Suppliers

China 27 United States 8 Global 35
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
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China
ProdList
3466
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LETOPHARM LIMITED
Tel
+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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China
ProdList
2384
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SPIRO PHARMA
Tel
Fax
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eric_feng1954@126.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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0371-86658258
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laboratory@coreychem.com
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China
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Shanghai Zeye Biotechnology Co., Ltd.
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021-61998551 13122364865
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sale1@shzysw.net
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cjbscvictory
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Shanghai tingchong biology science and technology co., ltd
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Shanghai Universal Biotech Co.,Ltd
Tel
13774214275
Email
zhouzz@univ-bio.com
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China
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
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China
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
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customer_service@efebio.com
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Shanghai Qiming Biological Technology Co., Ltd.
Tel
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CHINA
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Jiangxi Jianglan Pure Biological Reagent Co., Ltd.
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3245176082@qq.com
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Guangzhou Weijia Technology Co., Ltd.
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Shanghai Yuqi Biological Technology Co., Ltd.
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Shanghai Yijie Biological Technology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Wuhan Boot Biotechnology Co., Ltd.
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Shanghai Wowu Biological Technology Co., Ltd.
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Shanghai Weiwei Biological Technology Co., Ltd.
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Absin Bioscience Inc.
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364042-47-7, A 419259 trihydrochlorideRelated Search:


  • 7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • A 419259 trihydrochloride
  • A 419259
  • A419259
  • A-419259
  • RK 20449
  • RK20449
  • RK-20449
  • 7-[Trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-
  • A-419259 HCl
  • 364042-47-7