ChemicalBook > CAS DataBase List > AZM 475271

AZM 475271

Product Name: AZM 475271
CAS No.: 476159-98-5
Chemical Name: AZM 475271
Synonyms: M 475271;AZM 475271;AZM-475271,AZM475271;AZM-475271;M475271;M-475271;N-(2-Chloro-5-methoxyphenyl)-6-methoxy;N-(2-Chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine;4-Quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
CBNumber: CB12535662
Molecular Formula: C23H27ClN4O3
Formula Weight: 442.94
MOL File: 476159-98-5.mol

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AZM 475271 Property

Boiling point:: 556.1±50.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:43.15(Max Conc. mg/mL);97.42(Max Conc. mM)
form: A solid
pka: 8.92±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2572
Product name: AZM475271
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $97.33
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2572
Product name: AZM475271
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $691
Updated: 2025/07/31

Tocris

Product number: 3963
Product name: AZM475271
Purity: ≥99%(HPLC)
Packaging: 50
Price: $1088
Updated: 2021/12/16

Tocris

Product number: 3963
Product name: AZM475271
Purity: ≥99%(HPLC)
Packaging: 10
Price: $271
Updated: 2021/12/16

TRC

Product number: A808235
Product name: AZM475271
Packaging: 1mg
Price: $110
Updated: 2021/12/16

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AZM 475271 Chemical Properties,Usage,Production

Uses

AZM 475271 is an src tyrosine kinase inhibitor.

Biological Activity

AZM475271 (M475271) is an orally active, potent and selective inhibitor against src family kinases src and yes (IC50 = 25 nM & 10 nM, respectively; lck/VEGFR2/EGFR/csk/FGFR1 IC50 = 0.2/0.5/0.6/7.6/∼20 μM) th at effectively suppresses src-dependent cellular signaling events (26%/48% inhibition of 50 ng/mL VEGF-induced HUVEC proliferation/migration at 100 nM; 31%/72% inhibition of 10 ng/mL VEGF-induced Flk-1/Src phosphorylation in HUVECs at 300 nM) and exbihits anticancer efficacy both in cultures (70% PC-9/30% A549 proliferation inhibition at 1 μM) and in vivo (78%/100% PC-9 tumor growth suppression in mice via 10/50 mg/kg/day p.o.).

in vivo

AZM475271(50 mg/kg; p.o.; once daily for 32 days) reduces tumor volume and the effect can be enhanced by combination with Gemcitabine (100 mg/kg; i.p.; twice weekly for 32 days) in athymic nude mice injected with L3.6pl cells^[2].
AZM475271 (50 mg/kg; p.o.; once) has biological effective plasma concentration with 24 hours in healthy nude mice ^[2].

Animal Model:	Healthy nude mice^[2]
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.); once
Result:	The plasma concentration was 32.1 μM (14.206 ng/mL), 20 μM (8879 ng/mL), and 11.7 μM (5187 ng/mL) at 2, 6, and 24 hours after p.o..

Animal Model:	Athymic nude mice (injected with 1 X 10⁶ viable L3.6pl cells)^[2]
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.); once daily for 32 days
Result:	The median tumor volume was significantly less than that in control mice. After combination therapy, primary pancreatic tumor volume was significantly less than that seen with Gemcitabine alone. The incidence of liver metastasis was markedly reduced. Did not significantly change animal weight when used alone, but reduced animal weight combined with Gemcitabine. Has antiproliferative effect alone and in combination with Gemcitabine. Induce apoptosis in pancreatic carcinoma cells in vivo, maximum apoptotic effect was observed in the combination with Gemcitabine. Reduced microvessel density (MVD) alone and no significant difference in combination with Gemcitabine.

IC 50

Lck: 0.03 μM (IC₅₀)

storage

Store at RT

AZM 475271 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZM 475271 Suppliers

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476159-98-5, AZM 475271Related Search:

AZM 475271

M 475271

AZM-475271;M475271;M-475271

N-(2-Chloro-5-methoxyphenyl)-6-methoxy

4-Quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-

AZM-475271,AZM475271

N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

N-(2-Chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine

476159-98-5

Anticancer.