A 286982

ChemicalBook > CAS DataBase List > A 286982

Product Name: A 286982
CAS No.: 280749-17-9
Chemical Name: A 286982
Synonyms: A 286982;A 286982,Integrin,allosteric,LFA-1,A286982,Inhibitor,A-286982,inhibit,ICAM-1;(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one;2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-, (2E)-
CBNumber: CB12538269
Molecular Formula: C24H27N3O4S
Formula Weight: 453.55
MOL File: 280749-17-9.mol

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A 286982 Property

storage temp.: -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0595
Product name: A-286982
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0595
Product name: A-286982
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $428
Updated: 2022/05/15

Cayman Chemical

Product number: 27646
Product name: A286982
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 27646
Product name: A286982
Packaging: 50mg
Price: $577
Updated: 2024/03/01

Cayman Chemical

Product number: 27646
Product name: A286982
Packaging: 10mg
Price: $155
Updated: 2024/03/01

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A 286982 Chemical Properties,Usage,Production

Description

A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC₅₀ = 35 nM). It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC₅₀ = 44 nM).

Uses

A 286982 is a potent lymphocyte function-associated antigen-1 (LFA-1) and intracellular adhesion mol.-1 (ICAM-1) interaction inhibitor.

storage

Store at RT

References

[1]. liu, g., et al., discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. identification of an additional binding pocket based on an anilino diaryl sulfide lead. j med chem, 2000. 43(21): p. 4025-40.
[2]. katakai, t., k. habiro, and t. kinashi, dendritic cells regulate high-speed interstitial t cell migration in the lymph node via lfa-1/icam-1. j immunol, 2013. 191(3): p. 1188-99.
[3]. keating, s.m., et al., competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. protein sci, 2006. 15(2): p. 290-303.

A 286982 Preparation Products And Raw materials

Raw materials

Preparation Products

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280749-17-9, A 286982Related Search:

A 286982

(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one

2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-, (2E)-

A 286982,Integrin,allosteric,LFA-1,A286982,Inhibitor,A-286982,inhibit,ICAM-1

280749-17-9