ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate
- Product Name
- ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate
- CAS No.
- 1260169-02-5
- Chemical Name
- ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate
- Synonyms
- ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate;2-Aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester;Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 2-amino-, ethyl ester
- CBNumber
- CB12538971
- Molecular Formula
- C9H10N4O2
- Formula Weight
- 206.2
- MOL File
- 1260169-02-5.mol
ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H10N4O2/c1-2-15-9(14)6-7(10)12-13-5-3-4-11-8(6)13/h3-5H,2H2,1H3,(H2,10,12)
- InChIKey
- FKBUOZSNISVNHI-UHFFFAOYSA-N
- SMILES
- C12=C(C(OCC)=O)C(N)=NN1C=CC=N2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E938728
- Product name
- Ethyl2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CHM0392313
- Product name
- ETHYL-2-AMINOPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.79
- Updated
- 2021/12/16
- Product number
- 4928AA
- Product name
- Ethyl2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- 68R0547
- Product name
- 2-Amino-pyrazolo[1,5-a]pyrimidine-3-carboxylicacidethylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
- Product number
- CM167188
- Product name
- Ethyl2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate Chemical Properties,Usage,Production
Synthesis
102-52-3
6825-71-4
1260169-02-5
Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate (5.00 g, 29.38 mmol) and 1,1,3,3-tetramethoxypropane (14.50 mL, 88.15 mmol) were reacted in DMF (80 mL). AcOH (0.34 mL, 5.88 mmol) was added as a catalyst. The reaction mixture was stirred at 100 °C for 14 hours. After completion of the reaction, the solvent was removed by vacuum concentration. The residue was partitioned between DCM (50 mL) and water (50 mL) to separate the organic phase. The aqueous phase was extracted with DCM (100 mL x 3). The organic phases were combined, washed with brine (100 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: NH3 solution in MeOH (7 M)/DCM (v/v) = 1/100) to afford ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate as a light yellow solid (3.52 g, 58.1% yield).MS (ESI, cation) m/z: 207.1 [M+H]+; 1H NMR (400 MHz, CDCl3): δ (ppm) 8.60 (dd, J=4.40 Hz, 1.76 Hz, 1H), 8.46 (dd, J=6.76 Hz, 1.76 Hz, 1H), 6.86 (dd, J=6.72 Hz, 4.40 Hz, 1H), 4.50 (q, J=7.08 Hz, 2H), and 1.47 (t, J=7.08Hz, 3H).
References
[1] Patent: WO2015/73267, 2015, A1. Location in patent: Paragraph 318
[2] Patent: CN104650092, 2017, B. Location in patent: Paragraph 0463-0464; 0473-0474
[3] Patent: WO2011/3065, 2011, A2. Location in patent: Page/Page column 110-111
[4] Patent: US2015/336962, 2015, A1. Location in patent: Paragraph 0478
[5] Patent: WO2017/48702, 2017, A1. Location in patent: Paragraph 001169; 001170; 001172
ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate manufacturers
- Product
- ethyl 2-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate 1260169-02-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01