Choline tosylate
- Product Name
- Choline tosylate
- CAS No.
- 55357-38-5
- Chemical Name
- Choline tosylate
- Synonyms
- CHOLINE P-TOLUENESULFONATE SALT;2-Hydroxy-N,N,N-triMethylethanaMiniuM 4-Methylbenzenesulfonate;CHOLINE TOSYLATE;Choline toluenesulfonate;Choline p-toluenesulfonate;Choline 4-methylbenzenesulphonate salt;Choline 4-methylbenzenesulphonate salt 99%;(2-Hydroxyethyl)trimethylammonium toluene-4-sulfonate;(2-Hydroxyethyl)trimethylammonium toluene-4-sulphonate;(2-Hydroxyethyl)trimethylammoniumtoluene-4-sulphonate99%
- CBNumber
- CB1254402
- Molecular Formula
- C12H21NO4S
- Formula Weight
- 275.36
- MOL File
- 55357-38-5.mol
Choline tosylate Property
- Melting point:
- 95°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- crystalline solid
- color
- White
- Sensitive
- Light Sensitive/Hygroscopic
- InChI
- InChI=1S/C7H8O3S.C5H14NO/c1-6-2-4-7(5-3-6)11(8,9)10;1-6(2,3)4-5-7/h2-5H,1H3,(H,8,9,10);7H,4-5H2,1-3H3/q;+1/p-1
- InChIKey
- DVGVMQVOCJNXNJ-UHFFFAOYSA-M
- SMILES
- C1(S([O-])(=O)=O)C=CC(C)=CC=1.C(CO)[N+](C)(C)C
- CAS DataBase Reference
- 55357-38-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C433050
- Product name
- Cholinep-ToluenesulfonateSalt
- Packaging
- 10g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 099778
- Product name
- 2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 099778
- Product name
- 2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- P577
- Product name
- Cholinetosylate
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- 099778
- Product name
- 2-Hydroxy-N,N,N-trimethylethanaminium4-methylbenzenesulfonate
- Purity
- 95+%
- Packaging
- 100g
- Price
- $756
- Updated
- 2021/12/16
Choline tosylate Chemical Properties,Usage,Production
Uses
Choline p-Toluenesulfonate Salt is a useful intermediate as well as a choline acetyltransferase (CHAT) substrate.
Synthesis
A 500 mL reactor was charged at 25 ??C with 50 g (268.5 mmol) methyl tosylate and 100 mL acetone to which a solution of 25.1 g (281.6 mmol) N,N-dimethyl ethanolamine in 50.3 g acetone was added continuously at 25 ??C over 3 h. The dropping funnel was rinsed with additional acetone. The reaction mixture was stirred at 25 ??C for 20 h and the reaction progress was monitored by HPLC. When the level of methyltosylate was lower than 500 ppm the resulting suspension was cooled to 0 ??C over 150 min and the suspension was stirred at 0 ??C for 60 min. The product was collected by fdtration, washed two times with 175 mL acetone and dried under vacuum at 25 ??C to obtain 73.1 g (99 %) of choline tosylate as a white crystalline solid.
References
[1] Russian Chemical Bulletin, 1998, vol. 47, # 8, p. 1547 - 1549
[2] Tetrahedron Letters, 2009, vol. 50, # 28, p. 4092 - 4095
[3] Patent: JP5751578, 2015, B2. Location in patent: Paragraph 0017
[4] European Journal of Medicinal Chemistry, 2009, vol. 44, # 12, p. 4970 - 4977
[5] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988, vol. 37, p. 2293 - 2296
Choline tosylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Choline tosylate manufacturers
- Product
- Choline tosylate 55357-38-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11