(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane

Product Name: (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane
CAS No.: 192725-45-4
Chemical Name: (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane
Synonyms: Tert-Butyl(2S,4S,5S)-5-(2-(2,6-Dimethylphenoxy)Acetamido)-4-Hydro;tert-Butyl ((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)c;tert-Butyl ((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)carb;tert-Butyl ((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate;(2S,3S,5S)-2-(2,6-DIMETHYLPHENOXYACETYL)AMINO-3-HYDROXY-5-(T-BUTYLOXYCARBONYLAMINO)-1,6-DIPHENYLHEXANE;(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane;tert-butyl N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate;N-[(1S,3S,4S)-4-[[2-(2,6-DiMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]carbaMic Acid 1,1-DiMethylethyl Ester;Carbamic acid, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester
CBNumber: CB12546460
Molecular Formula: C33H42N2O5
Formula Weight: 546.7
MOL File: 192725-45-4.mol

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(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane Property

Boiling point:: 758.1±60.0 °C(Predicted)
Density: 1.133±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Chloroform, Dichloromethane, Methanol
form: Solid
pka: 12.33±0.46(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D476478
Product name: (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butyloxycarbonylamino)-1,6-diphenylhexane
Packaging: 250mg
Price: $1320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0031618
Product name: (2S,3S,5S)-2-(2,6-DIMETHYLPHENOXYACETYL)AMINO-3-HYDROXY-5-(TERT-BUTYLOXYCARBONYLAMINO)-1,6-DIPHENYLHEXANE
Purity: 95.00%
Packaging: 5MG
Price: $503.83
Updated: 2021/12/16

Matrix Scientific

Product number: 096823
Product name: tert-Butyl ((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

AK Scientific

Product number: 0000AB
Product name: tert-Butyl((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
Packaging: 250mg
Price: $1051
Updated: 2021/12/16

Matrix Scientific

Product number: 096823
Product name: tert-Butyl ((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

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(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butyloxycarbonylamino)-1,6-diphenylhexane (cas# 192725-45-4) is a compound useful in organic synthesis.

Synthesis

13335-71-2

144163-85-9

192725-45-4

Example 18. Preparation of (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane: tert-butyl (1S,3S,4S)-1 -benzyl-4-amino-3- hydroxy-5-phenylpentylcarbamate (38.5 mg, 0.1 mmol), 2, 6-dimethylphenoxyacetic acid (18.9 mg, 1.05 eq.), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (29.7 mg, 1.5 eq.) and 1-hydroxybenzotriazole (20.4 mg, 1.5 eq.) were dissolved in N,N-dimethylformamide (1 mL) and stirred for 4 min. Subsequently, N-methylmorpholine (27.5 μL, 2.5 eq.) was added to the reaction mixture and stirring was continued for 16 hours. After completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic phase was washed with 10% citric acid solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by silica gel column chromatography (3% methanol/dichloromethane) afforded a white solid product (240 mg, 76.7% yield).1H NMR (300 MHz, DMSO-D6) δ ppm: 1.31 (s, 9H), 1.39-1.55 (m, 2H), 2.14 (s, 6H), 2.61 (d, J = 6.99 Hz, 2H), 2.80 (d, J = 7.35 Hz, 2H), 3.61-3.70 (m, 1H), 3.84 (m, 1H), 4.00-4.11 (m, 2H), 4.20-4.38 (m, 1H), 4.99 (d, 1H), 6.66 (d, J = 9.19 Hz, 1H), 6.88-7.28 (m, 13H), 7.43 (d, J = 9.19 Hz, 13H), 7.43 (d, J = 9.19 Hz, 13H), 7.43 (d, J = 9.19 Hz, 13H), 7.43 (d, J = 6.99 Hz, 13H) 7.43 (d, J = 9.56 Hz, 1H); MS m/z 547.4 (M + H)+.

References

[1] Patent: EP1170289, 2002, A2. Location in patent: Page 41
[2] Patent: WO2008/27932, 2008, A2. Location in patent: Page/Page column 101
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 21, p. 3101 - 3103
[4] Letters in Organic Chemistry, 2018, vol. 15, # 2, p. 87 - 91

(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexane Suppliers

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192725-45-4, (2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-(tert-butoxycarbonyl)amino-1,6-diphenylhexaneRelated Search:

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(2S,3S,5S)-2-(2,6-DIMETHYLPHENOXYACETYL)AMINO-3-HYDROXY-5-(T-BUTYLOXYCARBONYLAMINO)-1,6-DIPHENYLHEXANE

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192725-45-4