3,5-DibroMo-1-Methylpyrazin-2(1H)-one
Uses- Product Name
- 3,5-DibroMo-1-Methylpyrazin-2(1H)-one
- CAS No.
- 87486-34-8
- Chemical Name
- 3,5-DibroMo-1-Methylpyrazin-2(1H)-one
- Synonyms
- 3,5-Dibromo-1-methylpyrazin-2-one;3,5-Dibromo-1-methylpyrazin-2(1H);3,5-DibroMo-1-Methylpyrazin-2(1H)-one;2(1H)-Pyrazinone, 3,5-dibroMo-1-Methyl-;2-methyl-1,3-thiazole-23-carboxylic acid;3,5-dibroMo-1-Methyl-1,2-dihydropyrazin-2-one
- CBNumber
- CB12550113
- Molecular Formula
- C5H4Br2N2O
- Formula Weight
- 267.91
- MOL File
- 87486-34-8.mol
3,5-DibroMo-1-Methylpyrazin-2(1H)-one Property
- Melting point:
- 98 °C
- Boiling point:
- 261.9±50.0 °C(Predicted)
- Density
- 2.20±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -6.54±0.70(Predicted)
- Appearance
- White to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D425910
- Product name
- 3,5-Dibromo-1-methylpyrazin-2(1h)-one
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W8976
- Product name
- 3,5-Dibromo-1-methylpyrazin-2(1H)-one
- Packaging
- 1g
- Price
- $123
- Updated
- 2021/12/16
- Product number
- FD42437
- Product name
- 3,5-Dibromo-1-methylpyrazin-2(1H)-one
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- W8976
- Product name
- 3,5-Dibromo-1-methylpyrazin-2(1H)-one
- Packaging
- 5g
- Price
- $246
- Updated
- 2021/12/16
- Product number
- FD42437
- Product name
- 3,5-Dibromo-1-methylpyrazin-2(1H)-one
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
3,5-DibroMo-1-Methylpyrazin-2(1H)-one Chemical Properties,Usage,Production
Uses
3,5-Dibromo-1-methylpyrazine-2(1H)-one can be used as a pharmaceutical synthesis intermediate, such as in the preparation of 5-bromo-3-(4-(1,4-dimethyl-3-oxopirarin-2-yl)phenylamino)-1-methylpyrazine-2(1H)-one, which can be prepared by reacting 1,2-dichlorobenzene with oxalyl bromide.
Synthesis
15219-34-8
25808-30-4
87486-34-8
To a suspension of 2-methylaminoacetonitrile hydrochloride (20 g, 142.0 mmol) in dichloromethane (DCM, 1300 mL) was slowly added oxalyl bromide (54 mL, 188.67 mmol), followed by the dropwise addition of N,N-dimethylformamide (DMF, 1.5 mL) at 0 °C. The reaction mixture was warmed to 55 °C and stirred for 16 hours. Upon completion of the reaction, the dichloromethane was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography using 2% methanol/dichloromethane (MeOH/CH2Cl2) as eluent to afford the target compound 3,5-dibromo-1-methylpyrazin2(1H)-one as a light yellow solid (34 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.1 (s, 1H), 3.4 (s, 3H).LC-MS analysis showed the molecular ion peak m/z 268.9 ([M + 1]+).
References
[1] Patent: WO2014/108820, 2014, A1. Location in patent: Page/Page column 27
[2] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 23; 24
3,5-DibroMo-1-Methylpyrazin-2(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-DibroMo-1-Methylpyrazin-2(1H)-one manufacturers
- Product
- 3,5-Dibromo-1-methylpyrazin-2(1H)-one 87486-34-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09