ChemicalBook > CAS DataBase List > 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

Product Name: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
CAS No.: 500011-86-9
Chemical Name: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
Synonyms: 3-broMo-1-(3-chloro-2-pyridinyl)-1H-Pyrazole-5-carboxylic acid;3-Bromo-1-(3-chloropyridin-2-yl);5-Bromo-2-(3-chloro-2-pyridyl)pyrazole-3-carboxylic acid;5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid;cas 500011-86-9;cas 500011-86-9 95%;coragen intermediate;Chlorantranliprole intermediate;intermediate of Chlorantranliprole;cas 500011-86-9 Coragen intermediate
CBNumber: CB12550168
Molecular Formula: C9H5BrClN3O2
Formula Weight: 302.51
MOL File: 500011-86-9.mol

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3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid Property

Melting point:: 197-200 °C
Boiling point:: 477.4±45.0 °C(Predicted)
Density: 1.92±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 20℃
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.39±0.36(Predicted)
color: White to Light Brown
Water Solubility: 8.84g/L at 20.3℃
InChI: InChI=1S/C9H5BrClN3O2/c10-7-4-6(9(15)16)14(13-7)8-5(11)2-1-3-12-8/h1-4H,(H,15,16)
InChIKey: FORBXGROTPOMEH-UHFFFAOYSA-N
SMILES: N1(C2=NC=CC=C2Cl)C(C(O)=O)=CC(Br)=N1
LogP: 1.5 at 25℃

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B124100
Product name: 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylicAcid
Packaging: 1g
Price: $280
Updated: 2021/12/16

Apolloscientific

Product number: OR916671
Product name: 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylicacid
Purity: 96%
Packaging: 25g
Price: $388
Updated: 2021/12/16

Matrix Scientific

Product number: 094753
Product name: 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
Purity: 95+%
Packaging: 250mg
Price: $439
Updated: 2021/12/16

ChemScene

Product number: CS-0046975
Product name: 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylicacid
Purity: 98.46%
Packaging: 25g
Price: $190
Updated: 2021/12/16

AK Scientific

Product number: X8007
Product name: 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylicacid
Packaging: 5g
Price: $194
Updated: 2021/12/16

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3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid Chemical Properties,Usage,Production

Uses

3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid is a useful building block and has been used in the synthesis of the pesticide Cyclaniliprole.

Flammability and Explosibility

Not classified

Synthesis

500011-85-8

124-38-9

500011-86-9

At -78 °C, 2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine (3.04 g, 11.8 mmol) was dissolved in anhydrous THF (25 mL), keeping the reaction temperature below -71 °C. LDA solution (6 mL, 2M) was added slowly and dropwise. The reaction mixture was stirred at -78 °C for 15 min and then bubbled with carbon dioxide gas for 10 min. Subsequently, the reaction system was slowly warmed to -57°C and continued to -20°C. Upon completion of the reaction, the reaction was quenched with water. The reaction mixture was concentrated and dissolved in water (100 mL) and ether (80 mL), and an aqueous NaOH solution (1N, 2 mL) was added. The aqueous phase was washed with ether and acidified with aqueous HCl (2N). The precipitated solid was filtered, washed with water and dried to give 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid (2 g, 59% yield) as a brown solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6274 - 6279
[2] Patent: CN105669643, 2016, A. Location in patent: Paragraph 0072; 0075; 0076
[3] Patent: WO2006/68669, 2006, A1. Location in patent: Page/Page column 19; 25
[4] Patent: WO2003/106427, 2003, A2. Location in patent: Page 18-19
[5] Patent: WO2004/67528, 2004, A1. Location in patent: Page 27

3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid 500011-86-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 200tons
Release date: 2025-08-21

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid 500011-86-9
Price: US $0.00-0.00/KG
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Purity: 99%
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Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid 500011-86-9
Price: US $100.00/kgkg
Min. Order: 1kgkg
Purity: 0.99
Supply Ability: 100
Release date: 2023-09-20

500011-86-9, 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acidRelated Search:

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3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid ISO 9001：2015 REACH

3-bromo-1-(3-chloro-2-pyridinyl)-1H-Pyrazole-5-carboxylic ac...

cas 500011-86-9 95%

3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid 95%

Intermediate of Chlorantraniliprole (Coragen)

cas 500011-86-9 Coragen intermediate

cas 500011-86-9 98% Coragen intermediate

5-bromo-2-(3-chloropyridin-2-yl)pyrazole-3-carboxylic acid

coragen intermediate

intermediate of Chlorantranliprole

Chlorantranliprole intermediate

cas 500011-86-9

3-Bromo-1- (3-chloro-2-pyridine) -1H-pyrazole-5-carboxylic acid

3-Bromo-1-(3-chloro-2-pyridinyl)-1H- pyrazole-5-carboxylic Acid [K Acid]

3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-carboxylic acid

500011-86-9