3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
- Product Name
- 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
- CAS No.
- 161833-42-7
- Chemical Name
- 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
- Synonyms
- Methyl 3-amino-4-bromothiophene-2-formate;Methyl 3-amino-4-bromothiophen-2-carboxylate;3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester;3-Amino-4-bromothiophen-2-carboxylic acid methyl ester;3-Amino-4-bromo-2-thiophenecarboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-4-bromo-, methyl ester;3-amino-4-bromo-2-Thiophenecarboxylic acid methyl ester (9CI ACI);2-Thiophenecarboxylic acid, 3-amino-4-bromo-, methyl ester (9CI, ACI)
- CBNumber
- CB12550461
- Molecular Formula
- C6H6BrNO2S
- Formula Weight
- 236.09
- MOL File
- 161833-42-7.mol
3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Property
- Boiling point:
- 333.6±37.0 °C(Predicted)
- Density
- 1.745±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- -0.20±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H6BrNO2S/c1-10-6(9)5-4(8)3(7)2-11-5/h2H,8H2,1H3
- InChIKey
- LWSWLXPUUCBUPI-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)SC=C(Br)C=1N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M286695
- Product name
- Methyl3-Amino-4-bromothiophene-2-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- P000508829
- Product name
- Methyl 3-amino-4-bromothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- P000508829
- Product name
- Methyl 3-amino-4-bromothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- P000508829
- Product name
- Methyl 3-amino-4-bromothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $172
- Updated
- 2021/12/16
- Product number
- P000508829
- Product name
- Methyl 3-amino-4-bromothiophene-2-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $342
- Updated
- 2021/12/16
3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Chemical Properties,Usage,Production
Synthesis
22288-78-4
161833-42-7
Example 2: Synthesis of 3-[(dimethylamino)diazenyl]-4-bromothiophene-2-carboxamide (Compound 2) Step a: Synthesis of methyl 3-amino-4-bromothiophene-2-carboxylate To a solution of methyl 3-aminothiophene-2-carboxylate (1 g, 6.36 mmol) in acetic acid (10 mL), a solution of bromine (0.32 mL, 6.36 mmol) in acetic acid (1 mL) was slowly added, and the addition process lasted for 5 min, and the reaction was carried out at room temperature. After addition, the reaction mixture was stirred at the same temperature for 16 hours. After completion of the reaction, the mixture was poured into ice-cold water and extracted with chloroform (3 x 100 mL). The organic layers were combined, washed sequentially with water and brine and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent petroleum ether-ethyl acetate (95:5, v/v) to afford the target product methyl 3-amino-4-bromothiophene-2-carboxylate as a light yellow solid (0.5 g, 33% yield) with a melting point of 58-60°C. The residue was extracted with water and sodium sulfate. 1H NMR (400 MHz, CDCl3): δ 7.29 (s, 1H), 5.63 (br s, 2H), 3.85 (s, 3H).
References
[1] Bulletin of the Korean Chemical Society, 2016, vol. 37, # 9, p. 1406 - 1414
[2] Patent: WO2010/29577, 2010, A2. Location in patent: Page/Page column 28-29
[3] Patent: US2010/68178, 2010, A1. Location in patent: Page/Page column 12
[4] Patent: CN106167497, 2016, A. Location in patent: Paragraph 0162; 0163; 0164
[5] Patent: EP2708540, 2014, A1. Location in patent: Paragraph 0137
3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester manufacturers
- Product
- 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester 161833-42-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09
- Product
- 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester 161833-42-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11