4-Piperidinecarboxylic acid, 2-oxo-
- Product Name
- 4-Piperidinecarboxylic acid, 2-oxo-
- CAS No.
- 24537-50-6
- Chemical Name
- 4-Piperidinecarboxylic acid, 2-oxo-
- Synonyms
- 2-Oxopiperidine-4-carboxy...;2-Oxopiperidine-4-carboxylic acid;4-Piperidinecarboxylic acid, 2-oxo-
- CBNumber
- CB12552809
- Molecular Formula
- C6H9NO3
- Formula Weight
- 143.14
- MOL File
- 24537-50-6.mol
4-Piperidinecarboxylic acid, 2-oxo- Property
- Boiling point:
- 437.0±38.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.62±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- O858825
- Product name
- 2-Oxopiperidine-4-carboxylicAcid
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-W006096
- Product name
- 2-Oxopiperidine-4-carboxylicacid
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $34
- Updated
- 2021/12/16
- Product number
- CS-W006096
- Product name
- 2-Oxopiperidine-4-carboxylicacid
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-W006096
- Product name
- 2-Oxopiperidine-4-carboxylicacid
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $197
- Updated
- 2021/12/16
- Product number
- 4H58-1-C7
- Product name
- 2-Oxopiperidine-4-carboxylic acid
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
4-Piperidinecarboxylic acid, 2-oxo- Chemical Properties,Usage,Production
Uses
2-Oxopiperidine-4-carboxylic Acid can be synthesized from 2-Hydroxyisonicitonic Acid (H942895), a compound used in the synthesis of selective inhibitors of neuropeptide Y Y5 inhibiting food intake. 2-Hydroxyisonicitonic Acid is also used in the optimization of p-subsite residues of HIV protease inhibitors.
Synthesis
22282-72-0
24537-50-6
Under nitrogen atmosphere, 2-hydroxyisonicotinic acid (500 g, 3.59 mol) was dissolved in methanol (10 L) and palladium hydroxide (150 g) was added to a 20 L autoclave. The reaction mixture was stirred at room temperature and 5 kg/cm2 hydrogen pressure for 18 hours. After confirming complete consumption of the feedstock by LCMS monitoring, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The resulting residue was ground with ether (2.5 L) and dried under vacuum to afford 2-oxopiperidine-4-carboxylic acid (450 g, 85% yield) as an off-white solid.1H NMR (500 MHz, DMSO-d6): δ 12.37 (s, 1H), 7.44 (s, 1H), 3.16-3.12 (m, 2H), 2.78-2.71 (m, 1H), 2.33-2.71 (m, 1H), 2.33-2.71 (m, 1H). 1H), 2.33-2.21 (m, 2H), 1.98-1.92 (m, 1H), 1.74-1.63 (m, 1H). LCMS (m/z): 144.2 [M++1].
References
[1] European Journal of Organic Chemistry, 2018, vol. 2018, # 46, p. 6486 - 6493
[2] Patent: WO2018/26798, 2018, A1. Location in patent: Page/Page column 33; 34
[3] Patent: US2007/191406, 2007, A1. Location in patent: Page/Page column 27
4-Piperidinecarboxylic acid, 2-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
4-Piperidinecarboxylic acid, 2-oxo- Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- marketing@accelachem.com
- Country
- China
- ProdList
- 10977
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1876
- Advantage
- 55
- Tel
- 031185291771 13832391721
- Fax
- 0311-67305698
- yaofeng2005@163.com
- Country
- China
- ProdList
- 967
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 025-66028182 17714375163
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16676
- Advantage
- 50
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58