ChemicalBook > CAS DataBase List > spiro<benzofuran-3(2H),4'-piperidine

spiro<benzofuran-3(2H),4'-piperidine

Product Name
spiro<benzofuran-3(2H),4'-piperidine
CAS No.
171-77-7
Chemical Name
spiro<benzofuran-3(2H),4'-piperidine
Synonyms
spiro;2H-Spiro[benzofuran-3,4'-piperidine];spiro
CBNumber
CB12561087
Molecular Formula
C12H15NO
Formula Weight
189.25
MOL File
171-77-7.mol
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spiro<benzofuran-3(2H),4'-piperidine Property

Boiling point:
320.4±42.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
10.60±0.20(Predicted)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
7755CV
Product name
2H-Spiro[benzofuran-3,4'-piperidine]
Packaging
100mg
Price
$181
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0388246
Product name
2H-SPIRO[BENZOFURAN-3,4'-PIPERIDINE]
Purity
95.00%
Packaging
5MG
Price
$504.88
Updated
2021/12/16
AK Scientific
Product number
7755CV
Product name
2H-Spiro[benzofuran-3,4'-piperidine]
Packaging
1g
Price
$546
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-345
Product name
2H-Spiro[1-benzofuran-3,4'-piperidine]
Purity
97%
Packaging
250mg
Price
$640
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-345
Product name
2H-Spiro[1-benzofuran-3,4'-piperidine]
Purity
97%
Packaging
1g
Price
$1280
Updated
2021/12/16
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spiro<benzofuran-3(2H),4'-piperidine Chemical Properties,Usage,Production

Synthesis

72374-35-7

171-77-7

Preparation of Example 20: A suspension of 1-benzyl-spiro[benzofuran-3,4-piperidine] (1.0 g, 3.58 mmol) was formed with 10% palladium carbon (750 mg) in ethanol (30 mL). To this suspension was added spiro H-benzofuran-3,4'-piperidine ammonium formate (1.13 g, 17.94 mmol) in one go. The reaction mixture was heated to reflux for 1.25 hours. After completion of the reaction, the mixture was cooled, filtered through Arbocel and the filter cake was washed with additional ethanol. The filtrate was evaporated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using a gradient elution of dichloromethane: methanol: 0.88 ammonia (100:0:0 to 90:10:1) to give 2H-spiro[benzofuran-3,4'-piperidinium] as a cream-colored solid (489 mg, 72% yield). The product was confirmed by 1HNMR (CDCl3, 400MHz): δ 1.72 (m, 2H), 1.80-1.96 (m, 2H), 2.70 (m, 2H), 3.11 (m, 2H), 4.40 (s, 2H), 6.79 (m, 1H), 6.88 (m, 1H), 7.13 (m, 1H), 7.14 (m, 1H). LRMS (ES+): m/z 190 [MH]+.

References

[1] Patent: WO2006/92731, 2006, A1. Location in patent: Page/Page column 46

spiro<benzofuran-3(2H),4'-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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spiro<benzofuran-3(2H),4'-piperidine Suppliers

China 29 India 1 United Kingdom 1 United States 4 Global 35
skychemical Co.Ltd
Tel
021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
1183
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57
Aloespharm Co., Ltd.
Tel
021-20960837
Fax
021-20960837
Email
market@aloespharm.com
Country
China
ProdList
1302
Advantage
55
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
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55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
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58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
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China
ProdList
22345
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58
Aikon International Limited
Tel
025-58859352 18068836627
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(5)02557626880
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Country
China
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Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
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3007523370@qq.com
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China
ProdList
52687
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58
Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
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30229
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Shanghai Lanle Bird Industrial Co., Ltd.
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15021845385
Email
765325601@qq.com
Country
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