ABT-492

Product Name: ABT-492
CAS No.: 189279-58-1
Chemical Name: ABT-492
Synonyms: Delafloxacin;Delafloxacine;Delafloxacin Impurity;WQ3034;CS-711;RX-3341;ABT-492;CS-2335;Delafloxacinum;ABT492/ABT-492
CBNumber: CB12561456
Molecular Formula: C18H12ClF3N4O4
Formula Weight: 440.76
MOL File: 189279-58-1.mol

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ABT-492 Property

Melting point:: 238-241℃
Boiling point:: 698.5±55.0 °C(Predicted)
Density: 1.796
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated)
pka: 5.49±0.50(Predicted)
form: powder
color: white to beige
InChI: InChI=1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)
InChIKey: DYDCPNMLZGFQTM-UHFFFAOYSA-N
SMILES: N1(C2=NC(N)=C(F)C=C2F)C2=C(C=C(F)C(N3CC(O)C3)=C2Cl)C(=O)C(C(O)=O)=C1
CAS DataBase Reference: 189279-58-1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1869
Product name: Delafloxacin
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1869
Product name: Delafloxacin
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $436
Updated: 2025/07/31

TCI Chemical

Product number: D6143
Product name: Delafloxacin
Packaging: 200MG
Price: $119
Updated: 2025/07/31

Cayman Chemical

Product number: 20314
Product name: Delafloxacin
Purity: 98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 20314
Product name: Delafloxacin
Purity: 98%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

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ABT-492 Chemical Properties,Usage,Production

Uses

Delafloxacin is a potent agent and broad-spectrum anionic fluoroquinolone against Streptococcus pneumoniae and diverse group of pathogens.

Biochem/physiol Actions

Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. Delafloxacin targets both DNA gyrase and topoisomerase IV, inhibiting DNA synthesis. Unlike most fluoroquinolones, delafloxacin is weakly acidic, which increases its potency in an acidic environments such as those existing in inflammatory cells and in skin and soft tissue infections. Delafloxacin shows good activity against most fluoroquinolone-resistant strains.

in vivo

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log₁₀ CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log₁₀ kill from initial burden for all S. aureus strains^[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t_1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)^[1].

Animal Model:	Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)^[1]
Dosage:	The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration:	0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result:	Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively. Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively. Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.

Animal Model:	Neutropenic mice^[1]
Dosage:	2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration:	Subcutaneous injection; 24 h
Result:	The maximum drug concentrations (C_max) concentrations ranged from 2 to 71 mg/L. AUC_0-∞ values ranged from 2.8 to 152 mg?h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t_1/2) ranged from 0.7 to 1 h.

IC 50

Quinolone

ABT-492 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT-492 Suppliers

China 167 India 4 United Kingdom 1 United States 14 Global 186

Shandong Jirun Biomedical Technology Co., Ltd.

Tel: 0539-0539-8613587 17661611089
Fax: qq2639273505
Email: 2639273505@qq.com
Country: China
ProdList: 207
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
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TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
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Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.

Tel: 0519-83984084
Fax: 0519-88776993
Email: sales@ydpharm.com
Country: China
ProdList: 119
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View Lastest Price from ABT-492 manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: ABT-492 189279-58-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-28

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Delafloxacin 189279-58-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: Delafloxacin 189279-58-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

189279-58-1, ABT-492Related Search:

2,6-DIAMINOPIMELIC ACID 2,4-Dihydroxypyridine

ABT-492

1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid

Delafloxacin

Delafloxacinum

3-Quinolinecarboxylic acid, 1-(6-aMino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-

WQ3034

ABT-492(WQ-3034)

ABT492/ABT-492

1-(6-aMino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

RX-3341

ABT-492/Delafloxacin

Delafloxacin, ABT-492

3-(6-Amino-3,5-difluoro-pyridin-2-ylamino)-2-{2,5-difluoro-4-[3-(3-methyl-2-oxo-butyl)-cyclobutyl]-benzoyl}-acrylic acid ethyl ester

DELAFLOXACIN;RX-3341;WQ-3034;ABT492

1-(6-Amino-3,5-difluoro-pyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-quinolin-3-carboxylic acid

Delafloxacin Impurity

Delafloxacin Free Acid

DELAFLOXACIN;DELAFLOXACINUM;RX-3341;WQ-3034;ABT492;ABT 492

CS-2335

DELAFLOXACINUM; RX-3341; WQ-3034; ABT492; ABT 492; ABT-492;WQ3034;WQ 3034

CS-711

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-...

Delafloxacin impurities7

Delafloxacine

2H5]-Delafloxacin

Delafloxacin API

3-?Quinolinecarboxylic acid, 1-?(6-?amino-?3,?5-?difluoro-?2-?pyridinyl)?-?6-?fluoro-?1,?4-?dihydro-?7-?[3-?(2-?methyl-?1-?oxopropoxy)&

Delafloxacin, 10 mM in DMSO

Delafloxacin - Bio-X ?

189279-58-1

C18H12ClF3N4O4

API