ChemicalBook > CAS DataBase List > 7-Deaza-2'-C-ethynyladenosine

7-Deaza-2'-C-ethynyladenosine

Product Name: 7-Deaza-2'-C-ethynyladenosine
CAS No.: 1044589-82-3
Chemical Name: 7-Deaza-2'-C-ethynyladenosine
Synonyms: NITD008;NITD008,NITD-008;2’-b-C-Ethynyltubercidin;2’-b-C-Ethynyl?tubercidin;7-Deaza-2'-C-ethynyladenosine;7-Deaza-2'-C-acetylene-adenosine;7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-ethynyl-β-D-ribofuranosyl)-;(2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CBNumber: CB12562529
Molecular Formula: C13H14N4O4
Formula Weight: 290.28
MOL File: 1044589-82-3.mol

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7-Deaza-2'-C-ethynyladenosine Property

Boiling point:: 631.8±55.0 °C(Predicted)
Density: 1?+-.0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 10.48±0.70(Predicted)
form: Solid
color: White to gray
InChI: InChI=1/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/s3
InChIKey: NKRAIOQPSBRMOV-YFEBQZRFNA-N
SMILES: C([C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O)#C |&1:1,2,3,7,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2409
Product name: NITD008
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $171
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2409
Product name: NITD008
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $559
Updated: 2025/07/31

Tocris

Product number: 6045
Product name: NITD008
Purity: ≥97%(HPLC)
Packaging: 1
Price: $177
Updated: 2021/12/16

ChemScene

Product number: CS-0012827
Product name: NITD008
Purity: >98.0%
Packaging: 5mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-0012827
Product name: NITD008
Purity: >98.0%
Packaging: 10mg
Price: $1350
Updated: 2021/12/16

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7-Deaza-2'-C-ethynyladenosine Chemical Properties,Usage,Production

Uses

NITD008 is an adenosine nucleoside analogue that inhibits proliferation of EV71, which is one of the major causative agents of Hand-Foot-Mouth Disease.

Biological Activity

NITD008 is a selective inhibitor of flaviviruses including dengue virus (EC50 = 0.64 μM), hepatitis C virus and Zika virus, and has also been shown to inhibit tick-borne flaviviruses in vitro. NITD008 has been reported to inhibit RNA-dependent RNA polymerase (RdRp), an essential protein of RNA viruses.

in vivo

NITD008 is orally bioavailable and has good pharmacokinetic properties. NITD008 exhibits the best pharmacokinetic parameters when formulated using 6 N of HCl (1.5 equimolar amount), 1 N of NaOH (pH adjusted to 3.5), and 100 mM citrate buffer (pH 3.5). Following i.v. injection, NITD008 has a high volume of distribution (3.71 L/kg) and a low systemic clearance (31.11 mL/min per kg), resulting in a long elimination half-life (t_1/2=4.99 h). After p.o. dosing, NITD008 is rapidly absorbed (time of peak plasma concentration=0.5 h), with a maximal plasma concentration of 3 μM and bioavailability of 48%. Treatment of the mice immediately after viral infection with 1 mg/kg of NITD008 does not reduce mortality, but treatment with 3 mg/kg partially protects and treatment with ≥10 mg/kg completely protects the infected mice from death. NITD008 can suppress peak viremia, decrease cytokine elevation, and prevent death^[1].

storage

Store at -20°C

7-Deaza-2'-C-ethynyladenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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1044589-82-3, 7-Deaza-2'-C-ethynyladenosineRelated Search:

7-Deaza-2'-C-ethynyladenosine

(2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

7-Deaza-2'-C-acetylene-adenosine

NITD008

7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-ethynyl-β-D-ribofuranosyl)-

NITD008,NITD-008

2’-b-C-Ethynyl?tubercidin

2’-b-C-Ethynyltubercidin

1044589-82-3