ChemicalBook > CAS DataBase List > N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine

N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine

Product Name
N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine
CAS No.
232271-19-1
Chemical Name
N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine
Synonyms
MDK1191;MDK-1191;TR 14035;TR-14035;TR 14035;TR14035;TR 14035;TR14035;MDK-1191;MDK1191;N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine;(S)-2-(2,6-DichlorobenzaMido)-3-(2',6'-diMethoxy-[1,1'-biphenyl]-4-yl)propanoic acid;(S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid;[1,1'-Biphenyl]-4-propanoic acid, α-[(2,6-dichlorobenzoyl)amino]-2',6'-dimethoxy-, (αS)-;(alphaS)-alpha-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy-[1,1'-biphenyl]-4-propanoic acid
CBNumber
CB12565722
Molecular Formula
C24H21Cl2NO5
Formula Weight
474.33
MOL File
232271-19-1.mol
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N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Property

Boiling point:
604.0±55.0 °C(Predicted)
Density 
1.333
storage temp. 
2-8°C
solubility 
DMSO: ≥ 41 mg/mL (86.44 mM)
form 
Powder
pka
3.53±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6908
Product name
TR14035
Purity
≥98%(HPLC)
Packaging
50
Price
$905
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573451
Product name
TR-14035
Purity
>98%
Packaging
100mg
Price
$1060.8
Updated
2021/12/16
ChemScene
Product number
CS-1812
Product name
TR-14035
Purity
95.14%
Packaging
50mg
Price
$1080
Updated
2021/12/16
Activate Scientific
Product number
AS43383
Product name
TR 14035
Purity
98% ee
Packaging
5mg
Price
$145
Updated
2021/12/16
Activate Scientific
Product number
AS43383
Product name
TR 14035
Purity
98% ee
Packaging
25mg
Price
$286
Updated
2021/12/16
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N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Chemical Properties,Usage,Production

Biological Activity

TR-14035 (SB 683698, MDK-1191) is a dual alpha4beta (α4β) integrin antagonist with IC50 values of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.

in vitro

TR-14035 blocks adhesion of RPMI-8866 cells to MAdCAM-Ig by 100% at 1 μM, with an approximate IC 50 of 0.01 μM.

target

TargetValue
α4β7
(Cell-free assay)		 7 nM
α4β1
(Cell-free assay)		 87 nM

storage

Store at -20°C

N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Suppliers

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232271-19-1, N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanineRelated Search:

Carbon tetrachloride 3,5-Dichlorobenzoic acid 4,4'-Dichlorodiphenyl sulfone Xylene Dichloroethane

  • MDK1191
  • MDK-1191
  • TR 14035;TR14035;MDK-1191;MDK1191
  • TR 14035
  • (S)-2-(2,6-DichlorobenzaMido)-3-(2',6'-diMethoxy-[1,1'-biphenyl]-4-yl)propanoic acid
  • N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine
  • (alphaS)-alpha-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy-[1,1'-biphenyl]-4-propanoic acid
  • TR-14035;TR 14035;TR14035
  • [1,1'-Biphenyl]-4-propanoic acid, α-[(2,6-dichlorobenzoyl)amino]-2',6'-dimethoxy-, (αS)-
  • (S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid[TR14035
  • TR-14035,autoimmune,disease,asthma,TR14035,Integrin,inhibit,TR 14035,allergic,inflammation,Inhibitor,alpha(4)
  • (S)-2-(2,6-Dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid
  • 232271-19-1