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GABEXATE

Product Name
GABEXATE
CAS No.
39492-01-8
Chemical Name
GABEXATE
Synonyms
GABEXATE;Gabexate USP/EP/BP;GabexateMesylateBase;4-[(6-Guanidinohexanoyl)oxy]benzoic acid ethyl ester;ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;diaminomethylidene-[6-(4-ethoxycarbonylphenoxy)-6-oxohexyl]ammonium;4-[[6-[[Amino(imino)methyl]amino]-1-oxohexyl]oxy]benzoic acid ethyl ester;Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethylester;[N'-[5-(4-ethoxycarbonylphenoxy)carbonylpentyl]carbamimidoyl]azanium methanesulfonate
CBNumber
CB1258637
Molecular Formula
C16H23N3O4
Formula Weight
321.37
MOL File
39492-01-8.mol
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GABEXATE Property

Boiling point:
472.2±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.83±0.70(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
G122803
Product name
Gabexate mesylate
Packaging
10mg
Price
$50
Updated
2021/12/16
AK Scientific
Product number
8132AH
Product name
Gabexate
Packaging
100mg
Price
$144
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002787
Product name
GABEXATE
Purity
95.00%
Packaging
50MG
Price
$976.27
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
18645
Product name
Gabexate
Packaging
25mg
Price
$1500
Updated
2021/12/16
AvaChem
Product number
2815B
Product name
Gabexate
Packaging
1g
Price
$245
Updated
2021/12/16
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GABEXATE Chemical Properties,Usage,Production

Originator

Gabexate Mesylate,Shangai Lansheng

Uses

Gabexate mesylate is used in combination with somatostatin and octreotide in the treatment of severe acute pancreatitis in elderly patients.

Definition

ChEBI: 4-[6-(diaminomethylideneamino)-1-oxohexoxy]benzoic acid ethyl ester is a benzoate ester.

Manufacturing Process

Guanidinocaproic acid p-tosyl salt and thionyl chloride were mixed together to react at the room temperature. An endothermic reaction occurred and the caproic acid gradually dissolved. Then the reaction mixture was left standing for 1 to 2 h and was extracted with ether. The lower oily layer and the ether layer were separated from each other and the lower layer was repeatedly washed with ether. Then the oily substance (caproic acid chloride) was added with benzoic acid ethyl ester in tetrahydrofuran, and the mixture was stirred. After the mixture became a uniform solution, of pyridine were gradually added. An exothermic reaction occurred and an oily substance came to be separated in the lower layer. After the completion of the reaction, the oily substance was washed with water and then recrystallized from hot water once or twice. Thus 4-(6-guanidino-hexanoyloxy)-benzoic acid ethyl ester salt was obtained as white crystals.
To obtained the base 4-(6-guanidino-hexanoyloxy)-benzoic acid ethyl ester the 4-(6-guanidino-hexanoyloxy)-benzoic acid ethyl ester salt must be treated by, for example, sodium hydroxide.
In practice it is usually used as mesylate.

Therapeutic Function

Enzyme inhibitor

Biological Activity

Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC 50 values are 9.4, 30, 41 and 110 mM respectively). Antithrombotic in vitro and in vivo . Also inhibits LPS-induced TNF- α production, probably by inhibiting NF- κ B and AP-1 activation.

GABEXATE Preparation Products And Raw materials

Raw materials

Preparation Products

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GABEXATE Suppliers

A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from GABEXATE manufacturers

Dideu Industries Group Limited
Product
Gabexate
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-03

39492-01-8, GABEXATERelated Search:


  • GABEXATE
  • GabexateMesylateBase
  • [N'-[5-(4-ethoxycarbonylphenoxy)carbonylpentyl]carbamimidoyl]azanium methanesulfonate
  • 4-[(6-Guanidinohexanoyl)oxy]benzoic acid ethyl ester
  • 4-[[6-[[Amino(imino)methyl]amino]-1-oxohexyl]oxy]benzoic acid ethyl ester
  • diaminomethylidene-[6-(4-ethoxycarbonylphenoxy)-6-oxohexyl]ammonium
  • Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethylester
  • Gabexate USP/EP/BP
  • ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate
  • 39492-01-8
  • Proteinase-activated receptor (PAR)