1-(5-fluoropyriMidin-2-yl)ethanone
- Product Name
- 1-(5-fluoropyriMidin-2-yl)ethanone
- CAS No.
- 905587-44-2
- Chemical Name
- 1-(5-fluoropyriMidin-2-yl)ethanone
- Synonyms
- 1-(5-Fluoropyrimidin-2-yl);2-Acetyl-5-fluoropyrimidine;1-(5-Fluoro-2-pyriMidyl)ethanone;1-(5-fluoropyriMidin-2-yl)ethanone;Ethanone, 1-(5-fluoro-2-pyrimidinyl)-;1-(5-fluoropyrimidin-2-yl)ethan-1-one
- CBNumber
- CB12589281
- Molecular Formula
- C6H5FN2O
- Formula Weight
- 140.12
- MOL File
- 905587-44-2.mol
1-(5-fluoropyriMidin-2-yl)ethanone Property
- Boiling point:
- 259.5±32.0 °C(Predicted)
- Density
- 1+-.0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.13±0.22(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F600160
- Product name
- 1-(5-Fluoropyrimidin-2-yl)ethanone
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W9324
- Product name
- 1-(5-Fluoropyrimidin-2-yl)ethanone
- Packaging
- 100mg
- Price
- $119
- Updated
- 2021/12/16
- Product number
- HCH0362065
- Product name
- 1-(5-FLUOROPYRIMIDIN-2-YL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.32
- Updated
- 2021/12/16
- Product number
- 144197
- Product name
- 1-(5-Fluoropyrimidin-2-yl)ethanone
- Purity
- 95%
- Packaging
- 1g
- Price
- $922
- Updated
- 2021/12/16
- Product number
- W9324
- Product name
- 1-(5-Fluoropyrimidin-2-yl)ethanone
- Packaging
- 5g
- Price
- $1167
- Updated
- 2021/12/16
1-(5-fluoropyriMidin-2-yl)ethanone Chemical Properties,Usage,Production
Synthesis
75-16-1
38275-55-7
905587-44-2
Method 5; Synthesis of 1-(5-fluoropyrimidin-2-yl)ethanone; To a round-bottomed flask containing 5-fluoropyrimidine-2-carbonitrile (Method 6, 1.50 g, 12.19 mmol) was added anhydrous tetrahydrofuran (30 mL) under nitrogen protection. The reaction system was cooled to 0 °C and methylmagnesium bromide solution (4.90 mL, 3.0 M ether solution, 14.62 mmol) was added slowly and dropwise. After keeping the reaction at 0 °C for 2 h, the reaction mixture was quenched with ice water and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure to afford the title compound as an oil (0.778 g, 46% yield).GC-MS showed molecular ion peaks m/z 140 (M); 1H NMR (CDCl3) δ 8.65 (s, 2H), 2.65 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 262 - 276
[2] Patent: WO2006/82392, 2006, A1. Location in patent: Page/Page column 120
[3] Patent: WO2007/49041, 2007, A1. Location in patent: Page/Page column 57
[4] Patent: WO2009/7753, 2009, A2. Location in patent: Page/Page column 57-58
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 5, p. 1376 - 1381
1-(5-fluoropyriMidin-2-yl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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