(±)12,13-DiHOME
- Product Name
- (±)12,13-DiHOME
- CAS No.
- 263399-35-5
- Chemical Name
- (±)12,13-DiHOME
- Synonyms
- (±)12,13-DiHOME;(±)12(13)-DiHOME MaxSpec Standard;9-Octadecenoic acid, 12,13-dihydroxy-, (9Z)-
- CBNumber
- CB12589786
- Molecular Formula
- C18H34O4
- Formula Weight
- 314.46
- MOL File
- 263399-35-5.mol
(±)12,13-DiHOME Property
- Boiling point:
- 476.0±30.0 °C(Predicted)
- Density
- 1.015±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 μ g/ml
- pka
- 4.78±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10009832
- Product name
- (±)12(13)-DiHOME
- Purity
- ≥98%
- Packaging
- 25μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 10009832
- Product name
- (±)12(13)-DiHOME
- Purity
- ≥98%
- Packaging
- 50μg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 10009832
- Product name
- (±)12(13)-DiHOME
- Purity
- ≥98%
- Packaging
- 100μg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 10009832
- Product name
- (±)12(13)-DiHOME
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $486
- Updated
- 2024/03/01
- Product number
- D679053
- Product name
- (±)-12,13-DIHOME
- Packaging
- 5mg
- Price
- $1110
- Updated
- 2021/12/16
(±)12,13-DiHOME Chemical Properties,Usage,Production
Uses
(±)-12,13-DIHOME is an exercise induced lipokine which has been shown to induce skeletal muscle fatty acid uptake. May be used in the treatment of neuropathic pain.
Definition
ChEBI: 12,13-DiHOME is a DiHOME obtained by formal dihydroxylation of the 12,13-double bond of octadeca-9,12-dienoic acid (the 9Z-geoisomer). It is a conjugate acid of a 12,13-DiHOME(1-).
in vivo
12,13-DiHOME (1 μg/kg; retro-orbitally injection; once daily for 2 weeks) acutely decreases levels of serum triglycerides in mice with high-fat diet model, and increases BAT uptake to defend cold[1].
| Animal Model: | Mice fed a high-fat diet[1] |
| Dosage: | 1 μg/kg |
| Administration: | Retro-orbitally injection; once daily for 2 weeks |
| Result: | Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA. Increased BAT-specific lipid uptake and improved oral lipid tolerance. Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake. |
| Animal Model: | To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1] |
| Dosage: | |
| Administration: | 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h |
| Result: | Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation. |
(±)12,13-DiHOME Preparation Products And Raw materials
Raw materials
Preparation Products
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