1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

Product Name: 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
CAS No.: 879487-10-2
Chemical Name: 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
Synonyms: 1-isopropyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-IsopropyL;1-(1-Methylethyl)-4-(4;1-(propan-2-yl)-4-(tetraM;1-Isopropylpyrazole-4-boronic acid,pinacol ester;1-Isopropyl-1H-pyrazol-4-boronic acid, pinacol ester;1-Isopropylpyrazole-4-boronic acid, pinacol ester 98%;1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1-Isopropyl-1H-pyrazole-4-boronic acid pinacol ester
CBNumber: CB12595004
Molecular Formula: C12H21BN2O2
Formula Weight: 236.12
MOL File: 879487-10-2.mol

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1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Property

Melting point:: 36-44°C
Boiling point:: 327.3±15.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
Flash point:: >110℃
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 2.13±0.10(Predicted)
color: White to Light yellow
InChIKey: OGYYMVGDKVJYSU-UHFFFAOYSA-N
CAS DataBase Reference: 879487-10-2

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 716243
Product name: 1-Isopropyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $147
Updated: 2025/07/31

Sigma-Aldrich

Product number: 716243
Product name: 1-Isopropyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97%
Packaging: 250mg
Price: $94.6
Updated: 2023/06/20

TCI Chemical

Product number: I1085
Product name: 1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 250MG
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: I1085
Product name: 1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 1G
Price: $86
Updated: 2025/07/31

TRC

Product number: I873848
Product name: 1-Isopropylpyrazole-4-boronicacid,pinacolester
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Chemical Properties,Usage,Production

Uses

1-Isopropylpyrazole-4-boronic acid, pinacol ester

Uses

1-Isopropyl-1H-pyrazole-4-boronic acid pinacol ester can be used as a reactant to synthesize:

Imidazo[1,2-a]pyrazine based phosphodiesterase 10A inhibitors.
Pyrido[3,4-d]pyrimidin-4-(3H)-one based KDM4 and KDM5 (histone lysine demethylase families) inhibitors.

Synthesis

75-30-9

269410-08-4

879487-10-2

GENERAL STEPS: 2-Iodopropane (1.14 g, 6.70 mmol, 0.67 mL) was slowly added dropwise to a solution of anhydrous N, N-dimethylformamide (20 mL) containing 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.00 g, 5.15 mmol) and cesium carbonate (3.49 g, 10.72 mmol) under nitrogen protection. N-dimethylformamide (20 mL) solution, and the reaction system was maintained at 0°C. After dropwise addition, stirring was continued at 0°C for 30 min. Subsequently, the ice water bath was removed and the reaction mixture was allowed to gradually warm up to room temperature with continuous stirring overnight. Upon completion of the reaction, the mixture was diluted with ethyl acetate (150 mL) and washed sequentially with saturated saline (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography (silica gel column, 12 g; eluent: heptane/ethyl acetate, gradient elution, 10%-30% ethyl acetate) to afford the target compound 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.69 g, 2.32 mmol, 57% yield). The product was analyzed by GC-MS (Method L9): retention time Rt = 3.86 min; mass spectrum m/z = 236 [M]+. 1H NMR (300 MHz, CDCl3, Method M2) δ 7.79 (s, 1H), 7.74 (s, 1H), 4.52 (p, J = 6.7 Hz, 1H), 1.50 (d, J = 6.7 Hz, 6H) , 1.32 (s, 12H).

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 - 6363
[2] Patent: WO2017/178416, 2017, A1. Location in patent: Page/Page column 114
[3] Patent: US2009/197862, 2009, A1. Location in patent: Page/Page column 46-47
[4] Patent: US2011/152273, 2011, A1. Location in patent: Page/Page column 73
[5] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 270 - 285

1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- Suppliers

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View Lastest Price from 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 879487-10-2
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-05

Career Henan Chemical Co

Product: 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 879487-10-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-10

Career Henan Chemical Co

Product: 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 879487-10-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-11

879487-10-2, 1H-Pyrazole, 1-(1-Methylethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-Related Search:

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879487-10-2