2,4-dichloro-5-MethylsulfanylpyriMidine
- Product Name
- 2,4-dichloro-5-MethylsulfanylpyriMidine
- CAS No.
- 7401-98-1
- Chemical Name
- 2,4-dichloro-5-MethylsulfanylpyriMidine
- Synonyms
- 2,4-dichloro-5-mercapto-pyrimidine;2,4-Dichloro-5-(methylthio)pyrimidine;1,3-dichloro-4-(methylthio)pyrimidine;2,4-dichloro-5-MethylsulfanylpyriMidine;PyriMidine, 2,4-dichloro-5-(Methylthio)-;2,4-Dichloro-5-(methylsulphanyl)pyrimidine
- CBNumber
- CB12596526
- Molecular Formula
- C5H4Cl2N2S
- Formula Weight
- 195.07
- MOL File
- 7401-98-1.mol
2,4-dichloro-5-MethylsulfanylpyriMidine Property
- Boiling point:
- 282.7±25.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.19±0.29(Predicted)
- form
- solid
- color
- Off-white to light yellow
- InChI
- InChI=1S/C5H4Cl2N2S/c1-10-3-2-8-5(7)9-4(3)6/h2H,1H3
- InChIKey
- PQLHCTKAQZYUMI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(SC)C(Cl)=N1
Safety
- WGK Germany
- WGK 3
- HS Code
- 2933599590
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Eye Dam. 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYV00003
- Product name
- 2,4-Dichloro-5-methylsulfanyl-pyrimidine
- Packaging
- 1g
- Price
- $114
- Updated
- 2026/04/30
- Product number
- D437283
- Product name
- 2,4-Dichloro-5-(methylsulfanyl)pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D437283
- Product name
- 2,4-Dichloro-5-(methylsulfanyl)pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D437283
- Product name
- 2,4-Dichloro-5-(methylsulfanyl)pyrimidine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD164889
- Product name
- 2,4-Dichloro-5-(methylthio)pyrimidine
- Packaging
- 500mg
- Price
- $105
- Updated
- 2021/12/16
2,4-dichloro-5-MethylsulfanylpyriMidine Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5-(methylsulfanyl)pyrimidine is used in preparation of the bridged heterocyclyl-substituted pyrimidine compounds and their pharmaceutical applications.
Synthesis
16350-59-7
7401-98-1
5-(Methylthio)pyrimidine-2,4(1H,3H)-dione (600 mg, 3.8 mmol) was used as a raw material and prepared according to the method described by Kopp F et al. in Organic Letters, 2007, 9, 1639-41. The raw material was dissolved in phosphoryl chloride (15 mL) and the reaction was stirred at 100 °C for 16 hours. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into ice water. The mixture was subsequently extracted with dichloromethane (20 mL × 2), and the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: dichloromethane/tetrahydrofuran = 100:100) to afford 2,4-dichloro-5-(methylthio)pyrimidine (520 mg, 70% yield) as a yellow oil.
References
[1] Patent: WO2015/89218, 2015, A1. Location in patent: Page/Page column 127; 128
[2] Patent: CN104583195, 2018, B. Location in patent: Paragraph 0369; 0370; 0374; 0375; 0376
[3] Patent: US2003/171359, 2003, A1. Location in patent: Page 29
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 19, p. 8099 - 8110
2,4-dichloro-5-MethylsulfanylpyriMidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-dichloro-5-MethylsulfanylpyriMidine manufacturers
- Product
- 2,4-dichloro-5-MethylsulfanylpyriMidine 7401-98-1
- Price
- US $1.80-3.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 88kg
- Release date
- 2019-07-31