ChemicalBook > CAS DataBase List > 4-chloro-7-Methoxyquinoline-6-carboxaMide

4-chloro-7-Methoxyquinoline-6-carboxaMide

Product Name
4-chloro-7-Methoxyquinoline-6-carboxaMide
CAS No.
417721-36-9
Chemical Name
4-chloro-7-Methoxyquinoline-6-carboxaMide
Synonyms
lenvaint-E;synthesis-024;synthesis-1-014;ine-6-carboxamide;oro-7-methoxyquinoL;Lenvatinib Impurity b;Lenvatinib Impurity 50;Lenvatinib Impurity LFS-B;4-chloro-7-Methoxy-6-QuinolinecarboxaMide;4-chloro-7-Methoxyquinoline-6-carboxaMide
CBNumber
CB12596687
Molecular Formula
C11H9ClN2O2
Formula Weight
236.65
MOL File
417721-36-9.mol
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4-chloro-7-Methoxyquinoline-6-carboxaMide Property

Melting point:
>205°C (dec.)
Boiling point:
426.7±45.0 °C(Predicted)
Density 
1.380±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
15.28±0.30(Predicted)
form 
Solid
color 
Off-White to Light Beige
InChI
InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15)
InChIKey
ZBTVNIDMGKZSGC-UHFFFAOYSA-N
SMILES
N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference
417721-36-9
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C369515
Product name
4-Chloro-7-methoxy-6-quinolinecarboxamide
Packaging
1g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC158634
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging
2g
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC158634
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging
500mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR53151
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Purity
97%
Packaging
5g
Price
$145
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-5-C6
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Purity
97%
Packaging
5G
Price
$160
Updated
2021/12/16
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4-chloro-7-Methoxyquinoline-6-carboxaMide Chemical Properties,Usage,Production

Description

4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).

Chemical Properties

light yellow powder

Uses

Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

4-chloro-7-Methoxyquinoline-6-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-7-Methoxyquinoline-6-carboxaMide Suppliers

China 330 India 4 United Kingdom 3 United States 7 Global 344
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View Lastest Price from 4-chloro-7-Methoxyquinoline-6-carboxaMide manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
4-chloro-7-Methoxyquinoline-6-carboxaMide 417721-36-9
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-12-11
Hebei Dangtong Import and export Co LTD
Product
4-chloro-7-Methoxyquinoline-6-carboxaMide 417721-36-9
Price
US $100.00-95.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17
Zibo Hangyu Biotechnology Development Co., Ltd
Product
4-chloro-7-Methoxyquinoline-6-carboxaMide 417721-36-9
Price
US $90.00-900.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-30

417721-36-9, 4-chloro-7-Methoxyquinoline-6-carboxaMideRelated Search:

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