ChemicalBook > CAS DataBase List > 4-chloro-7-Methoxyquinoline-6-carboxaMide

4-chloro-7-Methoxyquinoline-6-carboxaMide

Product Name
4-chloro-7-Methoxyquinoline-6-carboxaMide
CAS No.
417721-36-9
Chemical Name
4-chloro-7-Methoxyquinoline-6-carboxaMide
Synonyms
lenvaint-E;synthesis-024;synthesis-1-014;ine-6-carboxamide;oro-7-methoxyquinoL;Lenvatinib Impurity b;Lenvatinib Impurity 50;Lenvatinib Impurity LFS-B;4-chloro-7-Methoxy-6-QuinolinecarboxaMide;4-chloro-7-Methoxyquinoline-6-carboxaMide
CBNumber
CB12596687
Molecular Formula
C11H9ClN2O2
Formula Weight
236.65
MOL File
417721-36-9.mol
More
Less

4-chloro-7-Methoxyquinoline-6-carboxaMide Property

Melting point:
>205°C (dec.)
Boiling point:
426.7±45.0 °C(Predicted)
Density 
1.380±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
15.28±0.30(Predicted)
form 
Solid
color 
Off-White to Light Beige
InChI
InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15)
InChIKey
ZBTVNIDMGKZSGC-UHFFFAOYSA-N
SMILES
N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference
417721-36-9
More
Less

Safety

HS Code 
2933499090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C369515
Product name
4-Chloro-7-methoxy-6-quinolinecarboxamide
Packaging
1g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC158634
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging
500mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC158634
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC158634
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging
2g
Price
$120
Updated
2021/12/16
Apolloscientific
Product number
OR53151
Product name
4-Chloro-7-methoxyquinoline-6-carboxamide
Purity
97%
Packaging
5g
Price
$145
Updated
2021/12/16
More
Less

4-chloro-7-Methoxyquinoline-6-carboxaMide Chemical Properties,Usage,Production

Description

4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).

Chemical Properties

light yellow powder

Uses

Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

4-chloro-7-Methoxyquinoline-6-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-chloro-7-Methoxyquinoline-6-carboxaMide Suppliers

China 336 India 6 United Kingdom 3 United States 8 Global 353
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 4-chloro-7-Methoxyquinoline-6-carboxaMide manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-chloro-7-methoxyquinoline-6-carboxamide 417721-36-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-19
Jinan Million Pharmaceutical Co., Ltd
Product
4-chloro-7-Methoxyquinoline-6-carboxaMide 417721-36-9
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-12-11
Hebei Yanxi Chemical Co., Ltd.
Product
4-chloro-7-Methoxyquinoline-6-carboxaMide 417721-36-9
Price
US $0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
200T
Release date
2023-03-10

417721-36-9, 4-chloro-7-Methoxyquinoline-6-carboxaMideRelated Search:

7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea 7-methoxy-4-chloro-quinoline-6-carbonyl chloride Cyhalothrin Clioquinol Lansoprazole L-Glutamine, phenylmethyl ester 2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE Lenvatinib Impurity d Lenvatinib Impurity 12 Lenvatinib Impurity g synthesis-020 synthesis-022 4-Amino-3-chlorophenol hydrochloride lenvatinib Mesylate Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate 4-Amino-3-chlorophenol

  • 6-QuinolinecarboxaMide, 4-chloro-7-Methoxy-
  • 4-chloro-7-Methoxyquinoline-6-carboxaMide
  • 4-chloro-7-Methoxy-6-QuinolinecarboxaMide
  • Lenvatinib Impurity b
  • Lenvatinib Impurity LFS-B
  • synthesis-024
  • 4-Chloro-7-methoxy-quinoline-6-carboxylic acid amide
  • 4-Chloro-7-methoxyquinazoline-6-carboxamide
  • lenvaint-E
  • ine-6-carboxamide
  • oro-7-methoxyquinoL
  • synthesis-1-014
  • Lenvatinib Impurity 50
  • 417721-36-9
  • 477721-36-9
  • Intermediate
  • 417721-36-9