IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester
- Product Name
- IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester
- CAS No.
- 372198-69-1
- Chemical Name
- IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester
- Synonyms
- ethyl 6-broMoH-iMidazo[1,2-a]pyridine-3-carboxylate;6-bromoImidazo[1,2-a]pyridine-3-Carbocylic acid ethyl ester;6-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester;Midazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester;IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester
- CBNumber
- CB12597770
- Molecular Formula
- C10H9BrN2O2
- Formula Weight
- 269.09
- MOL File
- 372198-69-1.mol
IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester Property
- Density
- 1.60
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.29±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C10H9BrN2O2/c1-2-15-10(14)8-5-12-9-4-3-7(11)6-13(8)9/h3-6H,2H2,1H3
- InChIKey
- VMTDOHAWLUJHAI-UHFFFAOYSA-N
- SMILES
- C12=NC=C(C(OCC)=O)N1C=C(Br)C=C2
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- 4H23-9-0C
- Product name
- Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 089118
- Product name
- Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- J50739
- Product name
- Ethyl6-bromoimidazo[1,2-a]pyridine-3-carboxylate
- Packaging
- 10g
- Price
- $439
- Updated
- 2021/12/16
- Product number
- HCH0368990
- Product name
- ETHYL-6-BROMOIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.73
- Updated
- 2021/12/16
- Product number
- 089118
- Product name
- Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $573
- Updated
- 2021/12/16
IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester Chemical Properties,Usage,Production
Synthesis
1072-97-5
1004550-24-6
372198-69-1
General procedure for the synthesis of ethyl 6-bromoimidazo[1,2-A]pyridine-3-carboxylate from 2-amino-5-bromopyridine and 2-chloro-3-oxopropanoic acid ethyl ester potassium salt: In a sealed tube, 2-amino-5-bromopyridine (5.92 g, 34.2 mmol) and 2-chloro-3-oxopropanoic acid ethyl salt potassium salt (20.0 g, 106.0 mmol) were added to a solution of ethanol (140 mL) containing concentrated sulfuric acid (2.7 mL) in a solution of ethanol (140 mL). The reaction vessel was sealed by purging with nitrogen and the reaction was heated at 90 °C for 18 hours. Upon completion of the reaction, the resulting slurry was cooled to room temperature, filtered and concentrated under reduced pressure. The residue was diluted with ethyl acetate and washed sequentially with 1N sodium hydroxide solution and brine. The combined aqueous layers were back-extracted with a 95:5 solvent mixture of ethyl acetate/methanol. The combined organic extracts were dried with anhydrous sodium sulfate and filtered through a diatomaceous earth pad after decolorization with the addition of activated carbon. The filtrate was concentrated under reduced pressure and the residue was recrystallized with a 1:1 ethyl acetate/hexane solvent mixture (100 mL) to give 5.09 g (55% yield) of the target product, ethyl 6-bromoimidazo[1,2-A]pyridine-3-carboxylate, as an off-white solid. Mass spectrum (electrospray ionization) showed m/e 271.2 [M+H]+.
References
[1] Patent: WO2008/14219, 2008, A2. Location in patent: Page/Page column 41-42
IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester manufacturers
- Product
- IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester 372198-69-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-31
- Product
- IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester 372198-69-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-02