ChemicalBook > CAS DataBase List > 2-AMINO-5-BROMONICOTINAMIDE

2-AMINO-5-BROMONICOTINAMIDE

Product Name
2-AMINO-5-BROMONICOTINAMIDE
CAS No.
58483-98-0
Chemical Name
2-AMINO-5-BROMONICOTINAMIDE
Synonyms
2-aMino-5-broMopyridine-3-carboxaMide;2-amino-5-bromo-3-Pyridinecarboxamide;3-Pyridinecarboxamide, 2-amino-5-bromo-
CBNumber
CB12598065
Molecular Formula
C6H6BrN3O
Formula Weight
216.04
MOL File
58483-98-0.mol
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2-AMINO-5-BROMONICOTINAMIDE Property

Boiling point:
295.9±40.0 °C(Predicted)
Density 
1.802±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
13.98±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A596063
Product name
2-amino-5-bromonicotinamide
Packaging
50mg
Price
$175
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0363013
Product name
2-AMINO-5-BROMONICOTINAMIDE
Purity
95.00%
Packaging
1G
Price
$751.8
Updated
2021/12/16
AK Scientific
Product number
8666AB
Product name
2-Amino-5-bromonicotinamide
Packaging
10g
Price
$851
Updated
2021/12/16
Matrix Scientific
Product number
132153
Product name
2-Amino-5-bromonicotinamide
Purity
97%
Packaging
5g
Price
$2700
Updated
2021/12/16
Matrix Scientific
Product number
132153
Product name
2-Amino-5-bromonicotinamide
Purity
97%
Packaging
10g
Price
$4320
Updated
2021/12/16
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2-AMINO-5-BROMONICOTINAMIDE Chemical Properties,Usage,Production

Synthesis

52833-94-0

58483-98-0

2-Amino-5-bromonicotinic acid (2.0 g, 9.20 mmol) was used as raw material, which was mixed with HOBT (1.40 g, 11.2 mmol), EDCI (3.52 g, 18.4 mmol), Et3N (4.68 g, 46.0 mmol) and NH4Cl (2.48 g, 46.0 mmol) in DMF (100 mL) in DMF (100 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under vacuum and subsequently suspended in water and extracted with CH2Cl2. The organic layer was washed with brine, dried over Na2SO4 and concentrated to afford the crude product 2-amino-5-bromonicotinamide (1.80 g, yield: 80%), which could be used in subsequent steps without further purification. The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz) δ 8.14 (dd, J = 4.4 Hz, 2.4 Hz, 2H), 8.04 (s, 1H), 7.46 (s, 1H), 7.37 (s, 2H) and mass spectrum (M + H: 216/218).

References

[1] Patent: WO2014/205593, 2014, A1. Location in patent: Page/Page column 55
[2] Patent: WO2014/209727, 2014, A1. Location in patent: Page/Page column 52-53

2-AMINO-5-BROMONICOTINAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-BROMONICOTINAMIDE Suppliers

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58483-98-0, 2-AMINO-5-BROMONICOTINAMIDERelated Search:


  • 2-aMino-5-broMopyridine-3-carboxaMide
  • 3-Pyridinecarboxamide, 2-amino-5-bromo-
  • 2-amino-5-bromo-3-Pyridinecarboxamide
  • 58483-98-0