[4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid

Uses

Product Name: [4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid
CAS No.: 158937-25-8
Chemical Name: [4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid
Synonyms: 4-pentoxyl biphenyl boric acid;4'-Amyloxybiphenyl-4-boronic Acid;4'-hydroxy-4-biphenylboronic Acid;4'-Pentyloxyl-4-biphenylboronic aci;4'-Pentyloxybiphenyl-4-boronic Acid;4’-Pentyloxy-4-biphenylboronic acid;4'-Pentyloxyl-4-biphenylboronic acid;4-(4-pentoxyphenyl)phenyl]boronic acid;4'-(Pentyloxy)biphenyl-4-ylboronic acid;4-(4-n-pentyloxyphenyl)phenylboronic acid
CBNumber: CB12602777
Molecular Formula: C17H21BO3
Formula Weight: 284.16
MOL File: 158937-25-8.mol

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[4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid Property

Melting point:: 197°C(lit.)
Boiling point:: 459.9±55.0 °C(Predicted)
Density: 1.11
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 8.63±0.17(Predicted)
color: White to Almost white
CAS DataBase Reference: 158937-25-8

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2365
Product name: 4'-Pentyloxybiphenyl-4-boronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: P2365
Product name: 4'-Pentyloxybiphenyl-4-boronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $130
Updated: 2025/07/31

ChemScene

Product number: CS-W004379
Product name: (4'-(pentyloxy)-[1,1'-biphenyl]-4-yl)boronicacid
Purity: 99.72%
Packaging: 10g
Price: $135
Updated: 2021/12/16

ChemScene

Product number: CS-W004379
Product name: (4'-(pentyloxy)-[1,1'-biphenyl]-4-yl)boronicacid
Purity: 99.72%
Packaging: 5g
Price: $68
Updated: 2021/12/16

Matrix Scientific

Product number: 096721
Product name: (4'-(Pentyloxy)-[1,1'-biphenyl]-4-yl)boronic acid
Purity: 95+%
Packaging: 250mg
Price: $243
Updated: 2021/12/16

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[4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid Chemical Properties,Usage,Production

Uses

4-Pentoxybiphenylboronic acid can be used as a pharmaceutical synthesis intermediate, such as in the preparation of anidulafungin. Anidulafungin is a derivative of amphotericin B, a third-generation semi-synthetic echinocandin antifungal drug developed by Vicuron Pharmaceuticals in the United States, marketed under the brand name Eraxis, and approved for marketing in the United States in 2006. Compared with other echinocandin antifungals, anidulafungin has a larger volume of distribution and a broader spectrum of antibacterial activity.

Synthesis

63619-51-2

158937-25-8

General method: n-Butyl lithium (n-BuLi, 2.5 M, 7.4 mL, 18 mmol) was slowly added dropwise to a solution of methyl tertiary butyl ether (MTBE, 50 mL) of 4-bromo-4'-(pentyloxy)biphenyl (4.5 g, 13 mmol) at -20 °C under nitrogen protection. After stirring the reaction mixture for 2 h, it was cooled to -60 °C and tetrahydrofuran (THF, 6 mL) was added. Subsequently, a solution of triisopropoxyborane ((i-PrO)3B, 6.1 mL, 26 mmol) in methyl tert-butyl ether (MTBE, 8 mL) was slowly added dropwise to the reaction mixture and stirring was continued for 1 hour. The reaction mixture was gradually warmed to room temperature and stirred overnight. The reaction mixture was treated with 2M hydrochloric acid (HCl, 50 mL) for 10 minutes. The organic layer was separated and concentrated under reduced pressure to remove the solvent. Hexane (40 mL) was added to the residue and stirred for 10 minutes. After filtration, the filter cake was washed with a solvent mixture of hexane-methyl tert-butyl ether (8:1) to afford (4'-(pentyloxy)-[1,1'-biphenyl]-4-yl)boronic acid (15c, 3.7 g, 91.4% yield) as a white solid.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 196 - 208
[2] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000, vol. 339, p. 145 - 158

[4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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[4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid Suppliers

China 94 Europe 1 India 6 Japan 1 Switzerland 1 United Kingdom 3 United States 14 Global 120

Alfa Aesar

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View Lastest Price from [4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: [4"-(pentyloxy)[1,1"-biphenyl]-4-yl]boronic acid 158937-25-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: [4"-(pentyloxy)[1,1"-biphenyl]-4-yl]boronic acid 158937-25-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Cangzhou Wanyou New Material Technology Co.,Ltd

Product: boronic acid 158937-25-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20 Metric Ton/Metric Tons per Year
Release date: 2019-07-26

158937-25-8, [4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acidRelated Search:

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[4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid

[4'-(Pentyloxy)[1,1'-biphenyl]-4-yl]- Boronic acidc

4'-Pentyloxybiphenyl-4-boronic Acid

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4'-(pentyloxy)[1,1'-biphenyl]-4-yl]boronic acid

158937-25-8