2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid
- Product Name
- 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid
- CAS No.
- 35197-64-9
- Chemical Name
- 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid
- Synonyms
- 2-Bromo-4-(1,3-dioxoisoindolin-2-yl);2-bromo-4-(1,3-dioxoisoindol-2-yl)butanoic acid;2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid;2H-Isoindole-2-butanoic acid, α-bromo-1,3-dihydro-1,3-dioxo-
- CBNumber
- CB12603628
- Molecular Formula
- C12H10BrNO4
- Formula Weight
- 312.12
- MOL File
- 35197-64-9.mol
2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- FB116592
- Product name
- 2-Bromo-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 037057
- Product name
- 2-Bromo-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid
- Packaging
- 500mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- FB116592
- Product name
- 2-Bromo-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- HCH0043520
- Product name
- 2-BROMO-4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $682
- Updated
- 2021/12/16
- Product number
- HCH0043520
- Product name
- 2-BROMO-4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $750.75
- Updated
- 2021/12/16
2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid Chemical Properties,Usage,Production
Synthesis
3130-75-4
35197-64-9
GENERAL STEPS: The synthesis of 2-bromo-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid from 4-(1,3-dioxoisoindolin-2-yl)butanoic acid was carried out as follows: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid (3.00 g, 12.9 mmol) was mixed with thionyl chloride (20 mL ) were mixed and heated to reflux for 2 hours. Subsequently, bromine (2.06 g, 12.9 mmol) was added slowly over 4 hours while maintaining reflux. The reaction mixture was continued to be heated to reflux until complete consumption of the feedstock was confirmed by LC-MS, which took about 48 hours. Upon completion of the reaction, the excess thionyl chloride was removed under reduced pressure. Crushed ice was added to the residue and allowed to stand overnight. The precipitated white solid was filtered and dried in a vacuum oven to give 4.01 g of crude product, which could be used directly in subsequent steps without further purification. The product was confirmed by 1H NMR (270 MHz, methanol-D4): δ 2.19-2.38 (m, 1H), 2.39-2.58 (m, 1H), 3.83 (t, J=6.68 Hz, 2H), 4.37 (t, J=7.18 Hz, 1H), 7.73-7.91 (m, 4H). hplc analysis showed a purity of 71%. Retention time (Rt) was 1.12 min (System A, 30-80% acetonitrile, 3 min). Mass spectrometry (ESI+) analysis gave m/z 312 (M+H)+.
References
[1] Journal of Organic Chemistry, 1990, vol. 55, # 14, p. 4246 - 4255
[2] Chemical and Pharmaceutical Bulletin, 1986, vol. 34, # 5, p. 2078 - 2089
[3] Patent: WO2005/75471, 2005, A2. Location in patent: Page/Page column 126; 127-128
[4] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 194,198
[5] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 21, p. 2765 - 2770
2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid manufacturers
- Product
- 2-BroMo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid 35197-64-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-16