LaniceMine

Product Name: LaniceMine
CAS No.: 153322-05-5
Chemical Name: LaniceMine
Synonyms: LaniceMine;(1S)-1-phenyl-2-pyridin-2-ylethanamine;2-PyridineethanaMine, a-phenyl-, (aS)-;2-Pyridineethanamine, α-phenyl-, (αS)-;(S)-1-phenyl-2-(pyridin-2-yl)ethanamine;(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE
CBNumber: CB12611425
Molecular Formula: C13H14N2
Formula Weight: 198.27
MOL File: 153322-05-5.mol

More

Less

LaniceMine Property

Boiling point:: 307.7±27.0 °C(Predicted)
Density: 1.097±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide
form: neat oil
pka: 8.29±0.10(Predicted)
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 9002129
Product name: Lanicemine
Purity: ≥95%
Packaging: 5mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 9002129
Product name: Lanicemine
Purity: ≥95%
Packaging: 10mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 9002129
Product name: Lanicemine
Purity: ≥95%
Packaging: 25mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 9002129
Product name: Lanicemine
Purity: ≥95%
Packaging: 50mg
Price: $300
Updated: 2024/03/01

TRC

Product number: L173950
Product name: Lanicemine
Packaging: 5mg
Price: $40
Updated: 2021/12/16

More

Less

LaniceMine Chemical Properties,Usage,Production

Description

Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC₅₀ = 4-7 μM) that binds to sites within the channel pore with a K_i value of 0.56-2.1 μM. Compared to ketamine , lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.

Uses

Lanicemine is a non-selective voltage-dependant NMDA channel blocker. It is a potential anti-depressant which does not cause psychotomimetic activity. Potential anti-hypertensive agent.

in vitro

previous study with lanicemine and ketamine found that both compounds could bind with low-to-moderate affinity to sites within the nmda channel pore, exhibit strong voltage dependence, and have similar lack of nr2a vs nr2b subunit selectivity [1].

in vivo

in animal study, cortical eeg recordings were obtained from rats trained to perform an auditory detection task for food reward. results showed that both lanicemine and ketamine produced pronounced dose-dependent elevations in spontaneous gamma-band eeg, but only gamma changes for ketamine were tightly coupled to increases in locomotor activity, indicating that lanicemine not only engaged brain circuits involved in the generation of gamma-eeg, but also influenced these networks independent of the broader systemslevel disruptions typical of ketamine [1].

IC 50

4-7 μm

References

[1] g. sanacora, m. a. smith, s. pathak, et al. lanicemine: a low-trapping nmda channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. molecular psychiatry 19(9), 978-985 (2014).

LaniceMine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LaniceMine Suppliers

China 28 United States 5 Global 33

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 10199
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8617531153977
Email: allison@yan-xi.com
Country: China
ProdList: 5856
Advantage: 58

Changzhou Xuanye Technology Co., Ltd

Tel: 15195022192
Email: 279776773@qq.com
Country: China
ProdList: 2011
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Tel: 1701086315
Fax: 1701086315@qq.com
Email: dexuanpharma@126.com
Country: China
ProdList: 9475
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

More

Less

View Lastest Price from LaniceMine manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Lanicemine 153322-05-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-09-05

153322-05-5, LaniceMineRelated Search:

LaniceMine

2-PyridineethanaMine, a-phenyl-, (aS)-

(1S)-1-phenyl-2-pyridin-2-ylethanamine

(S)-1-phenyl-2-(pyridin-2-yl)ethanamine

2-Pyridineethanamine, α-phenyl-, (αS)-

(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE

153322-05-5